Nanostructured membranes with precisely engineered nanopores were fabricated on a thin silicon nitride membrane, using a combination of bulk micromachining and focused-ion-beam drilling. These membranes are designed to preserve microscale blood channel dimensions, thereby permitting the red cell shape change that enhances gas exchange in the pulmonary capillary. The membranes were tested for their mechanical stability and the results were verified with finite element analysis. Initial studies have proven the membranes to be robust, and capable of withstanding pressures typically experienced in blood oxygenator channels. A novel MEMS-based blood oxygenation system employing the nanoporous membranes is also presented. The oxygenation system i...
End-stage lung diseases may result in death either by oxygenation and carbon dioxide exchange insuff...
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.Includes...
Chronic lower respiratory disease is highly prevalent in the United States, and there remains a need...
Lung disease is one of the most important causes of high morbidity in preterm infants. In this work,...
Current artificial lungs, or membrane oxygenators, have limited gas exchange capacity due to their i...
In cases of severe lung or heart failure, extracorporeal membrane oxygenation (ECMO) is a life-savin...
Extracorporeal membrane oxygenation (ECMO) is a life support system that circulates the blood throug...
In this work, we study alveolar-like microfluidic devices with a horizontal membrane arrangement tha...
Hemodialysis using hollow-fiber membranes provides life-sustaining treatment for nearly 2 million pa...
Nanoimprint lithography is emerging as a viable contender for fabrication of large-scale arrays of 5...
Extracorporeal membrane oxygenation (ECMO) is a life support technology capable of providing full re...
Chronic lower respiratory disease afflicts over 5% of the United States population, leading to over ...
International audienceWe have developed and tested a novel microfluidic device for blood oxygenation...
End-stage lung diseases may result in death either by oxygenation and carbon dioxide exchange insuff...
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.Includes...
Chronic lower respiratory disease is highly prevalent in the United States, and there remains a need...
Lung disease is one of the most important causes of high morbidity in preterm infants. In this work,...
Current artificial lungs, or membrane oxygenators, have limited gas exchange capacity due to their i...
In cases of severe lung or heart failure, extracorporeal membrane oxygenation (ECMO) is a life-savin...
Extracorporeal membrane oxygenation (ECMO) is a life support system that circulates the blood throug...
In this work, we study alveolar-like microfluidic devices with a horizontal membrane arrangement tha...
Hemodialysis using hollow-fiber membranes provides life-sustaining treatment for nearly 2 million pa...
Nanoimprint lithography is emerging as a viable contender for fabrication of large-scale arrays of 5...
Extracorporeal membrane oxygenation (ECMO) is a life support technology capable of providing full re...
Chronic lower respiratory disease afflicts over 5% of the United States population, leading to over ...
International audienceWe have developed and tested a novel microfluidic device for blood oxygenation...
End-stage lung diseases may result in death either by oxygenation and carbon dioxide exchange insuff...
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.Includes...
Chronic lower respiratory disease is highly prevalent in the United States, and there remains a need...