Anti-Proliferative Compound Candidate of White Turmeric (Curcuma zedoaria)

Malignant disease or cancer progression burden the community after decades. This tumor formation or tumorigenesis involves cell proliferation. Protein Kinases (MAPK9s) is key proteins of regulating the growth and viability of cells physiologically and pathologically. Rhizomes of Curcuma zedoaria or zedoary or white turmeric is used as a health supplement. The aim of this study was to obtained candidate proteins for anti-proliferative using the docking method between the protein MAPK9 and the active compound obtained from the crude extract of white turmeric i.e. demethoxycurcumin, curcumenol and germacrone. The result s hows that complex MAPK-demethoxycurcumin have the lowest binding affinity -8.4 Kkal/mol, while MAPK-curcumenol was -8 Kkal/mol, and MAPK-Germacrone was -6.2 Kkal/mol, it determined the potential activity cell proliferation.Penyakit ganas atau perkembangan kanker membebani masyarakat setelah beberapa dekade. Pembentukan tumor atau tumorigenesis ini melibatkan proliferasi sel. Protein Kinase (MAPK9s) adalah protein kunci yang mengatur pertumbuhan dan kelangsungan hidup sel secara fisiologis dan patologis. Rimpang Curcuma zedoaria atau zedoary atau kunyit putih digunakan sebagai suplemen kesehatan. Penelitian ini bertujuan untuk mendapatkan calon protein antiproliferatif dengan metode docking antara protein MAPK9 dengan senyawa aktif yang diperoleh dari ekstrak kasar kunyit putih yaitu demethoxycurcumin, curcumenol dan germacrone. Hasil penelitian menunjukkan bahwa kompleks MAPK-demethoxycurcumin memiliki afinitas ikatan terendah -8.4 Kkal/mol, sedangkan MAPK-curcumenol -8 Kkal/mol, dan MAPK-Germacrone -6.2 Kkal/mol. Hal ini menentukan potensi aktivitas proliferasi sel. Anti-proliferative curcumenol demethoxycurcumine germacrone in-silico white turmeri