Potensi Tablet Ekstrak Rumput Kebar Sebagai Estrogenik Pada Mencit Putih Betina

Abstract: Kebar grass (Biophytum petersianum) has chemical compounds with estrogenic effects that have the potential to increase fertility for humans and animals. To make it practical to use, kebar grass extract has been made in the form of tablets. The experimental animals used were mice (Mus musculus) divided into 5 treatment groups, consisting of a group that received 0.065 mg/20g BW of Kebar grass extract tablets, 0.13 mg/20g BW K2, and 0.065 mg/20g BW kebar grass extract. dose of 0.065 mg/20g BW. As a negative control using (CMC Na 1%) and positive control (ethinyl estradiol 7.8 × 10⁻⁵ mg/20g BW). Each experimental animal was given 1 ml of the test solution orally on the first day of the mice experiencing the estrus phase. Observations were made every 12 hours for 7 days. The results of the statistical analysis showed a significantly different effect with the negative control p<0.05. Tablet dosage forms and all treatment doses of coriander grass extract were able to shorten the estrus cycle to 79.2 - 84 hours or 3.3 - 3.5 days and prolong the estrus phase to 93.6 - 96 hours. Tablets and extracts can also affect vascularization and increase the weight of the ovaries and uterus. The conclusion is that the dosage forms of tablets and all treatment doses of coriander grass extract have an estrogenic effect.Abstrak: Rumput kebar (Biophytum petersianum) mempunyai kandungan kimia dengan efek estrogenik yang berpotensi untuk meningkatkan kesuburan bagi manusia maupun hewan.. Agar praktis digunakan maka esktrak rumput kebar telah dibuat dalam bentuk sediaan tablet. Hewan coba yang digunakan yaitu Mencit (Mus musculus) sebanyak 25 ekor dibagi menjadi 5 kelompok perlakuan, terdiri dari kelompok yang memperoleh tablet ekstrak rumput kebar K1 dosis 0,065 mg/20g BB, K2 dosis 0,13 mg/20g BB, dan ekstrak rumput kebar dosis 0,065 mg/20g BB. Sebagai Kontrol negatif menggunakan (CMC Na 1%) dan kontrol positif (etinil estradiol 7,8 × 10⁻⁵ mg/20g BB). Setiap hewan coba diberikan 1 ml larutan uji per oral saat hari pertama mencit mengalami fase estrus. Pengamatan dilakukan setiap 12 jam selama 7 hari. Hasil analisis statistik menunjukkan pengaruh yang berbeda nyata dengan kontrol negatif p