Immunotherapies have become an essential part of cancer treatment. Long-term curative response relies on the ability of immunotherapies to re-establish efficient anti-tumor immunity in malignancies. Immunotherapies currently have limited potential to circumvent the immunosuppressive tumor microenvironment and to elicit efficient immune response in tumors poorly infiltrated by immune cells. In this context, engineered oncolytic adenoviruses that encode immunostimulatory molecules represent promising therapeutic options to potentiate cancer therapies, such as immune checkpoint inhibitors and adoptive cell transfer. Oncolytic adenoviruses are immunogenic cell lytic agents that stimulate de novo immunity through spreading of tumor epitopes. A f...
This thesis concentrates on exploring novel agents in the pathogenesis of cutaneous T cell lymphomas...
Implementation of immunotherapy in many cancer types has achieved positive results in tumor control ...
Cancer immunotherapy, or activating immunity against malignant cells, is a promising treatment optio...
In the history of oncology scientists have tried to treat cancer in numerous different ways. Traditi...
Immuunivasteen tarkistuspisteiden estäjähoidolla pyritään tehostamaan elimistön omaa immuunivastetta...
Adoptive T-cell therapies (ACT) are emerging as essential treatments for cancer patients with immuno...
In 2012 WHO announced cancer as the leading cause of death. Every day 20 000 people die due to cance...
Tausta ja tavoitteet: Syöpä on globaalisti yksi yleisimmistä kuolinsyistä, ja hoitoresistenttien ta...
The effects of cancer immunotherapy are based on activating and utilizing the immune system to fight...
Maailmalla sairastuu vuosittain yhä enemmän ihmisiä syöpään. Uusien syöpähoitojen tarve on ollut jat...
Summary1 SummaryCancer patients have a better clinical outcome when their tumours display marked inf...
Haiman duktaalinen adenokarsinooma on yleistyvä pahanlaatuinen sairaus. Kirurgia on edelleen ainoa h...
Gene therapy with oncolytic adenoviruses is a promising novel treatment modality for cancer. Adenovi...
Replicating oncolytic viruses (OVs) that are able to selectively destroy malignant cells are emergi...
The treatment results of many cancers have improved, but there are still challenges, such as metasta...
This thesis concentrates on exploring novel agents in the pathogenesis of cutaneous T cell lymphomas...
Implementation of immunotherapy in many cancer types has achieved positive results in tumor control ...
Cancer immunotherapy, or activating immunity against malignant cells, is a promising treatment optio...
In the history of oncology scientists have tried to treat cancer in numerous different ways. Traditi...
Immuunivasteen tarkistuspisteiden estäjähoidolla pyritään tehostamaan elimistön omaa immuunivastetta...
Adoptive T-cell therapies (ACT) are emerging as essential treatments for cancer patients with immuno...
In 2012 WHO announced cancer as the leading cause of death. Every day 20 000 people die due to cance...
Tausta ja tavoitteet: Syöpä on globaalisti yksi yleisimmistä kuolinsyistä, ja hoitoresistenttien ta...
The effects of cancer immunotherapy are based on activating and utilizing the immune system to fight...
Maailmalla sairastuu vuosittain yhä enemmän ihmisiä syöpään. Uusien syöpähoitojen tarve on ollut jat...
Summary1 SummaryCancer patients have a better clinical outcome when their tumours display marked inf...
Haiman duktaalinen adenokarsinooma on yleistyvä pahanlaatuinen sairaus. Kirurgia on edelleen ainoa h...
Gene therapy with oncolytic adenoviruses is a promising novel treatment modality for cancer. Adenovi...
Replicating oncolytic viruses (OVs) that are able to selectively destroy malignant cells are emergi...
The treatment results of many cancers have improved, but there are still challenges, such as metasta...
This thesis concentrates on exploring novel agents in the pathogenesis of cutaneous T cell lymphomas...
Implementation of immunotherapy in many cancer types has achieved positive results in tumor control ...
Cancer immunotherapy, or activating immunity against malignant cells, is a promising treatment optio...