This report documents the program and the outcomes of Dagstuhl Seminar 22362 "Model-Driven Engineering of Digital Twins".Digital twins are an emerging concept with the potential for revolutionising the way we interact with the physical world. Digital twins can be used for improved analysis and understanding of complex systems as well as for control and transformation of these systems. Digital twins are themselves complex software systems, posing novel software-engineering challenges, which have so far not been sufficiently addressed by the software-engineering research community.The seminar aimed as a key outcome to contribute to a solid research roadmap for the new Software Engineering subdiscipline of Model-Based Development of Digital Tw...