Immunotherapies controlling the adaptive immune system are firmly established, but regulating the innate immune system remains much less explored. The intrinsic interactions between nanoparticles and phagocytic myeloid cells make these materials especially suited for engaging the innate immune system. However, developing nanotherapeutics is an elaborate process. Here, we demonstrate a modular approach that facilitates efficiently incorporating a broad variety of drugs in a nanobiologic platform. Using a microfluidic formulation strategy, we produced apolipoprotein A1–based nanobiologics with favorable innate immune system–engaging properties as evaluated by in vivo screening. Subsequently, rapamycin and three small-molecule inhibitors were ...
Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transpl...
Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transpl...
Immunological complexity in atherosclerosis warrants targeted treatment of specific inflammatory cel...
Immunotherapies controlling the adaptive immune system are firmly established, but regulating the in...
Immunotherapies controlling the adaptive immune system are firmly established, but regulating the in...
In the slipstream of targeting the adaptive immune system, innate immunotherapy strategies are being...
Immunotherapy has firmly established itself as a compelling avenue for treating disease. Although ma...
Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transpl...
Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transpl...
Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transpl...
Immunological complexity in atherosclerosis warrants targeted treatment of specific inflammatory cel...
Immunotherapies controlling the adaptive immune system are firmly established, but regulating the in...
Immunotherapies controlling the adaptive immune system are firmly established, but regulating the in...
In the slipstream of targeting the adaptive immune system, innate immunotherapy strategies are being...
Immunotherapy has firmly established itself as a compelling avenue for treating disease. Although ma...
Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transpl...
Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transpl...
Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transpl...
Immunological complexity in atherosclerosis warrants targeted treatment of specific inflammatory cel...