Anatomically informed multi-level fiber tractography for improved sensitivity of white matter bundle reconstruction in diffusion MRI

Neurosurgery planning is an important application of fiber tractography which requires the results to be consistent and accurate. Deterministic tractography methods are generally characterized by high specificity and limited sensitivity, whereas the opposite typically holds for probabilistic methods. Here, we propose a multi-level fiber tractography strategy that takes fiber branching into account and incorporates an anatomical prior to provide a balance between true and false positive reconstructions. We evaluated our approach on the MASSIVE dataset and compared its performance to the existing state of art. (Abstract #0855