Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has recently be achieved for procaspase‐3. This success opens up new possibilities for small‐molecule intervention in biology, and reveals proenzymes as a whole new class of potential targets
AbstractProteases regulate many essential functions in biology, yet their precise roles are only beg...
The 26S proteasome is the principal protease for regulated intracellular proteolysis. This multi-sub...
International audienceIn cells, protein degradation is a key pathway for the destruction of abnormal...
Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has...
Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has...
Most proteases are expressed as inactive precursors, known as zymogens. Studies to explore zymogen a...
ABSTRACT: Combination anticancer therapy typically con-sists of drugs that target different biochemi...
The use of small molecule drugs to inhibit active protein targets has revolutionised the treatment o...
The ubiquitin-proteasome system has emerged as essential sets of reactions involved in many biologic...
From seminal evidence in the early 2000s, the opportunity to drive the specific knockdown of a prote...
The ubiquitin-proteasome system (UPS) is a critical regulator of cellular protein levels and activit...
AbstractBackground: Traditional protease inhibitors target the active site of the enzyme. However, s...
Due to the conserved nature of protease active sites, it has been difficult to develop protease inhi...
There are several challenges towards the development and clinical use of small molecule inhibitors, ...
180 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.Programmed cell death, also k...
AbstractProteases regulate many essential functions in biology, yet their precise roles are only beg...
The 26S proteasome is the principal protease for regulated intracellular proteolysis. This multi-sub...
International audienceIn cells, protein degradation is a key pathway for the destruction of abnormal...
Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has...
Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has...
Most proteases are expressed as inactive precursors, known as zymogens. Studies to explore zymogen a...
ABSTRACT: Combination anticancer therapy typically con-sists of drugs that target different biochemi...
The use of small molecule drugs to inhibit active protein targets has revolutionised the treatment o...
The ubiquitin-proteasome system has emerged as essential sets of reactions involved in many biologic...
From seminal evidence in the early 2000s, the opportunity to drive the specific knockdown of a prote...
The ubiquitin-proteasome system (UPS) is a critical regulator of cellular protein levels and activit...
AbstractBackground: Traditional protease inhibitors target the active site of the enzyme. However, s...
Due to the conserved nature of protease active sites, it has been difficult to develop protease inhi...
There are several challenges towards the development and clinical use of small molecule inhibitors, ...
180 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.Programmed cell death, also k...
AbstractProteases regulate many essential functions in biology, yet their precise roles are only beg...
The 26S proteasome is the principal protease for regulated intracellular proteolysis. This multi-sub...
International audienceIn cells, protein degradation is a key pathway for the destruction of abnormal...
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