Graph databases have become an increasingly popular choice for the management of the massive network data sets arising in many contemporary applications. We investigate the effectiveness of path indexing for accelerating query processing in graph database systems, using as an exemplar the widely used open-source Neo4j graph database. We present a novel path index design which supports efficient ordered access to paths in a graph dataset. Our index is fully persistent and designed for external memory storage and retrieval. We also describe a compression scheme that exploits the limited differences between consecutive keys in the index, as well as a workload-driven approach to indexing. We demonstrate empirically the speed-ups achieved by our...