Three novel differential amplifier topologies using double gate a-IGZO TFTs on flexible substrate are presented in this paper. The designs exploit positive feedback and a load with self-biased top gate to achieve the highest static gain in single stage a-IGZO amplifiers reported to date. After fabrication, the three amplifiers exhibit respectively a static gain of 14 dB, 21.5 dB and 30 dB, with a bandwidth of 2 kHz, 400 Hz, and 150 Hz. Also, for each circuit the input referred noise has been measured to be 420 μVrms, 195 μVrms and 146 μVrms, respectively. Based on these results, the a-IGZO amplifier providing the highest gain is suitable as front-end for heart rate measurements and, with some further optimization verified in simulation, can...