Accurate CFD simulation of coupled outdoor wind flow and indoor air flow is essential for the design and evaluation of natural cross-ventilation strategies for buildings. It is widely recognized that CFD simulations can be very sensitive to the large number of computational parameters that have to be set by the user. Therefore, detailed and generic sensitivity analyses of the impact of these parameters on the simulation results are important to provide guidance for the execution and evaluation of future CFD studies. A detailed review of the literature indicates that there is a lack of extensive generic sensitivity studies for CFD simulation of natural cross-ventilation. In order to provide such a study, this paper presents a series of coupl...