Background: The mammalian target of rapamycin (mTOR) protein is important for cellular growth and homeostasis. The presence and prognostic significance of inappropriate mTOR activation have been reported for several cancers. Mammalian target of rapamycin inhibitors, such as everolimus (RAD001), are in development and show promise as anti-cancer drugs; however, the therapeutic effect of everolimus on oesophageal squamous cell carcinoma (OSCC) remains unknown. Methods: Phosphorylation of mTOR (p-mTOR) was evaluated in 167 resected OSCC tumours and 5 OSCC cell lines. The effects of everolimus on the OSCC cell lines TE4 and TE11 in vitro and alone or in combination with cisplatin on tumour growth in vivo were evaluated. Results: Mammalian targe...
BackgroundPatients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) demonstra...
BackgroundPatients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) demonstra...
Esophageal squamous cell carcinoma (ESCC) remains one of the most aggressive cancers with poor progn...
Background: The mammalian target of rapamycin (mTOR) protein is important for cellular growth and ho...
The mammalian target of rapamycin (mTOR) has recently emerged as a promising target for therapeutic ...
mTOR (mechanistic target of rapamycin) functions as the central regulator for cell proliferation, gr...
<div><p>The mammalian target of rapamycin (mTOR), a vital component of signaling pathways involving ...
Everolimus is an oral agent that targets the mammalian target of rapamycin (mTOR) pathway. This stud...
Despite impressive treatment advances, few options for refractory or relapsed Hodgkin Lymphoma (HL) ...
Phosphorylated (pi-) protein kinase B (AKT) is commonly expressed in nasopharyngeal carcinoma (NPC) ...
Despite impressive treatment advances, few options for refractory or relapsed Hodgkin Lymphoma (HL) ...
The aim was to determine the potential of the allosteric mammalian target of rapamycin inhibitor, ev...
The mammalian target of rapamycin (mTOR), a vital component of signaling pathways involving PI3K/AKT...
BackgroundPatients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) demonstra...
Mammalian target of rapamycin (mTOR) regulates cellular functions by integrating intracellular signa...
BackgroundPatients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) demonstra...
BackgroundPatients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) demonstra...
Esophageal squamous cell carcinoma (ESCC) remains one of the most aggressive cancers with poor progn...
Background: The mammalian target of rapamycin (mTOR) protein is important for cellular growth and ho...
The mammalian target of rapamycin (mTOR) has recently emerged as a promising target for therapeutic ...
mTOR (mechanistic target of rapamycin) functions as the central regulator for cell proliferation, gr...
<div><p>The mammalian target of rapamycin (mTOR), a vital component of signaling pathways involving ...
Everolimus is an oral agent that targets the mammalian target of rapamycin (mTOR) pathway. This stud...
Despite impressive treatment advances, few options for refractory or relapsed Hodgkin Lymphoma (HL) ...
Phosphorylated (pi-) protein kinase B (AKT) is commonly expressed in nasopharyngeal carcinoma (NPC) ...
Despite impressive treatment advances, few options for refractory or relapsed Hodgkin Lymphoma (HL) ...
The aim was to determine the potential of the allosteric mammalian target of rapamycin inhibitor, ev...
The mammalian target of rapamycin (mTOR), a vital component of signaling pathways involving PI3K/AKT...
BackgroundPatients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) demonstra...
Mammalian target of rapamycin (mTOR) regulates cellular functions by integrating intracellular signa...
BackgroundPatients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) demonstra...
BackgroundPatients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) demonstra...
Esophageal squamous cell carcinoma (ESCC) remains one of the most aggressive cancers with poor progn...