A database of decaying homogeneous, isotropic turbulence is constructed including reference direct numerical simulations at two different Reynolds numbers and a large number of corresponding large-eddy simulations at various subgrid resolutions. Errors in large-eddy simulation as a function of physical and numerical parameters are investigated. In particular, employing the Smagorinsky subgrid parametrization, the dependence of modeling and numerical errors on simulation parameters is quantified. The interaction between these two basic sources of error is shown to lead to their partial cancellation for several flow properties. This leads to a central paradox in large-eddy simulation related to possible strategies that can be followed to impr...