We give an algorithmic and lower-bound framework that facilitates the construction of subexponential algorithms and matching conditional complexity bounds. It can be applied to a wide range of geometric intersection graphs (intersections of similarly sized fat objects), yielding algorithms with running time $2^{O(n^{1-1/d})}$ for any fixed dimension $d \geq 2$ for many well known graph problems, including Independent Set, $r$-Dominating Set for constant $r$, and Steiner Tree. For most problems, we get improved running times compared to prior work; in some cases, we give the first known subexponential algorithm in geometric intersection graphs. Additionally, most of the obtained algorithms work on the graph itself, i.e., do not require any g...