DNA has emerged as a highly versatile construction material for nanometer-sized structures and sophisticated molecular machines and circuits. The successful application of nucleic acid based systems greatly relies on their ability to autonomously sense and act on their environment. In this feature article, the development of DNA-based strategies to dynamically control protein activity via oligonucleotide triggers is discussed. Depending on the desired application, protein activity can be controlled by directly conjugating them to an oligonucleotide handle, or expressing them as a fusion protein with DNA binding motifs. To control proteins without modifying them chemically or genetically, multivalent ligands and aptamers that reversibly inhi...
The ability to target DNA specifically at any given position within the genome allows many intriguin...
The fundamental concept of effective molarity is observed in a variety of biological processes, such...
DNA-based molecular circuits allow autonomous signal processing, but their actuation has relied most...
DNA has emerged as a highly versatile construction material for nanometer-sized structures and sophi...
Inspired by signaling networks in living cells, DNA-based programming aims for the engineering of bi...
Integrating dynamic DNA nanotechnology with protein-controlled actuation will expand our ability to ...
Nature uses dynamic molecular platforms for the recruitment of weakly associating proteins into high...
While DNA is widely regarded as the molecule of life, the molecule on its own is nothing but an info...
The regulation of protein uptake and secretion is crucial for (inter)cellular signaling. Mimicking t...
We report here the rational design and optimization of an antibody-responsive, DNA-based device that...
Nucleic acid base sequence of proteins plays a crucial role in the expression of gene. The gene is r...
The ability to target DNA specifically at any given position within the genome allows many intriguin...
The fundamental concept of effective molarity is observed in a variety of biological processes, such...
DNA-based molecular circuits allow autonomous signal processing, but their actuation has relied most...
DNA has emerged as a highly versatile construction material for nanometer-sized structures and sophi...
Inspired by signaling networks in living cells, DNA-based programming aims for the engineering of bi...
Integrating dynamic DNA nanotechnology with protein-controlled actuation will expand our ability to ...
Nature uses dynamic molecular platforms for the recruitment of weakly associating proteins into high...
While DNA is widely regarded as the molecule of life, the molecule on its own is nothing but an info...
The regulation of protein uptake and secretion is crucial for (inter)cellular signaling. Mimicking t...
We report here the rational design and optimization of an antibody-responsive, DNA-based device that...
Nucleic acid base sequence of proteins plays a crucial role in the expression of gene. The gene is r...
The ability to target DNA specifically at any given position within the genome allows many intriguin...
The fundamental concept of effective molarity is observed in a variety of biological processes, such...
DNA-based molecular circuits allow autonomous signal processing, but their actuation has relied most...