Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniproteins generates potent androgen receptor (AR) binders and a clear insight into the structure–activity relationship of such coactivator mimics concerning helix length
The estrogen receptor (ER) is ligand-regulated nuclear hormone receptor and an important therapeutic...
Ligands for the androgen receptor (AR), androgens and antiandrogens alike, have therapeutic value in...
We have previously identified a family of novel androgen receptor (AR) ligands that, upon binding, e...
Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniprotein...
Item does not contain fulltextInsertion of 3 to 4 mutations, based on in silico modelling, in a dive...
A classical approach to treating prostate cancer uses antagonist ligands - so-called anti-androgens,...
The androgen receptor (AR) mediates the various actions of androgens and is responsible for the male...
The androgen receptor (AR) plays important roles in gene expression regulation, sexual phenotype mai...
The mutation-driven transformation of clinical anti-androgen drugs into agonists of the human androg...
Androgen receptor (AR), as a member of the nuclear receptor (NR) superfamily, regulates the gene tra...
Prostate cancer is a leading killer of men in the industrialized world. Underlying this disease is t...
When a small molecule binds to the androgen receptor (AR), a conformational change can occur which i...
In this study, molecular simulations have been combined with site-directed mutagenesis experiments t...
<p>When a small molecule binds to the androgen receptor (AR), a conformational change can occur whic...
This work focuses on designing specific miniprotein interactions using computational models and then...
The estrogen receptor (ER) is ligand-regulated nuclear hormone receptor and an important therapeutic...
Ligands for the androgen receptor (AR), androgens and antiandrogens alike, have therapeutic value in...
We have previously identified a family of novel androgen receptor (AR) ligands that, upon binding, e...
Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniprotein...
Item does not contain fulltextInsertion of 3 to 4 mutations, based on in silico modelling, in a dive...
A classical approach to treating prostate cancer uses antagonist ligands - so-called anti-androgens,...
The androgen receptor (AR) mediates the various actions of androgens and is responsible for the male...
The androgen receptor (AR) plays important roles in gene expression regulation, sexual phenotype mai...
The mutation-driven transformation of clinical anti-androgen drugs into agonists of the human androg...
Androgen receptor (AR), as a member of the nuclear receptor (NR) superfamily, regulates the gene tra...
Prostate cancer is a leading killer of men in the industrialized world. Underlying this disease is t...
When a small molecule binds to the androgen receptor (AR), a conformational change can occur which i...
In this study, molecular simulations have been combined with site-directed mutagenesis experiments t...
<p>When a small molecule binds to the androgen receptor (AR), a conformational change can occur whic...
This work focuses on designing specific miniprotein interactions using computational models and then...
The estrogen receptor (ER) is ligand-regulated nuclear hormone receptor and an important therapeutic...
Ligands for the androgen receptor (AR), androgens and antiandrogens alike, have therapeutic value in...
We have previously identified a family of novel androgen receptor (AR) ligands that, upon binding, e...
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