Optimization of the elution range in micellar electrokinetic capillary chromatography

The resolution of neutra! solutes in micellar electrokinetic capillary chromatagrophy is influenced by the migration time of the electroosmotie flow, tEoF' the migration time of the micelles, tMe, and the capacity factors of the solutes, k. The resolution of a separation can be improved by increasing the elution window and by optimizing the capacity factors of the solutes. The influence of the buffer pH, surfactant concentration and organic modifier content of the electrolyte system on both the elution window and the capacity factors was investigated