An experimental investigation into the constant stress amplitude compression–compression fatigue behavior of closed-cell aluminum foam, both with and without lateral constraint, was conducted. Results show that while the early stages of strain accumulation due to fatigue loading are independent of constraint, the rapid strain accumulation stage behaviors are sensitive to the constraint. This was ascribed to the noticeable hardening with plastic deformation observed under constraint during quasi-static loading, which in turn reduces the effective maximum stress experienced by the foam specimen during fatigue loading. This was demonstrated through a simple empirical model that connects fatigue strain accumulation without constraint to that un...