The metabolism of malignant cells differs significantly from that of healthy cells and thus, it is possible to perform metabolic imaging to reveal not only the exact location of a tumor, but also intratumoral areas of high metabolic activity. Herein, we demonstrate the feasibility of metabolic tumor imaging using signal-enhanced 1-13C-pyruvate-d3, which is rapidly enhanced via para-hydrogen, and thus, the signal is amplified by several orders of magnitudes in less than a minute. Using as a model, human melanoma xenografts injected with signal-enhanced 1-13C-pyruvate-d3, we show that the conversion of pyruvate into lactate can be monitored along with its kinetics, which could pave the way for rapidly detecting and monitoring changes in tumor...
Most tumor cells rely on aerobic glycolysis instead of mitochondrial oxidative phosphorylation (OXPH...
The purpose of this work was to study the anatomic and metabolic changes that occur with tumor progr...
Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer patients ...
The metabolism of malignant cells differs significantly from that of healthy cells and thus, it is p...
The exchange reaction between hyperpolarized 1-13C pyruvate and lactate, catalysed by the enzyme lac...
Hyperpolarized (HP) 13C magnetic resonance imaging (MRI) is a novel imaging modality that is powerfu...
13C MRI of hyperpolarized [1-13C]pyruvate metabolism has been used in oncology to detect disease, in...
An extraordinary new technique using hyperpolarized 13C-labeled pyruvate and taking advantage of inc...
One major challenge in cancer biology is to monitor cancer metabolism in vivo with the goal of impro...
Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient ...
Abnormalities of tumor metabolism can be exploited for molecular imaging. PET imaging of 18F-FDG is ...
Reprogramming of energy metabolism in the development of prostate cancer can be exploited for a bett...
Detection of early tumor responses to treatment can give an indication of clinical outcome. Positron...
Detection of early tumor responses to treatment can give an indication of clinical outcome. Positron...
Tumors develop a characteristic microenvironment depending on their specific genetic mutations. The ...
Most tumor cells rely on aerobic glycolysis instead of mitochondrial oxidative phosphorylation (OXPH...
The purpose of this work was to study the anatomic and metabolic changes that occur with tumor progr...
Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer patients ...
The metabolism of malignant cells differs significantly from that of healthy cells and thus, it is p...
The exchange reaction between hyperpolarized 1-13C pyruvate and lactate, catalysed by the enzyme lac...
Hyperpolarized (HP) 13C magnetic resonance imaging (MRI) is a novel imaging modality that is powerfu...
13C MRI of hyperpolarized [1-13C]pyruvate metabolism has been used in oncology to detect disease, in...
An extraordinary new technique using hyperpolarized 13C-labeled pyruvate and taking advantage of inc...
One major challenge in cancer biology is to monitor cancer metabolism in vivo with the goal of impro...
Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient ...
Abnormalities of tumor metabolism can be exploited for molecular imaging. PET imaging of 18F-FDG is ...
Reprogramming of energy metabolism in the development of prostate cancer can be exploited for a bett...
Detection of early tumor responses to treatment can give an indication of clinical outcome. Positron...
Detection of early tumor responses to treatment can give an indication of clinical outcome. Positron...
Tumors develop a characteristic microenvironment depending on their specific genetic mutations. The ...
Most tumor cells rely on aerobic glycolysis instead of mitochondrial oxidative phosphorylation (OXPH...
The purpose of this work was to study the anatomic and metabolic changes that occur with tumor progr...
Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer patients ...