The development of highly efficient enantioselective olefin metathesis catalysts is a significant challenge. Using optically pure chiral cyclic (alkyl)(amino)carbene (ChiCAAC) ligands combined with preliminary mechanistic insights and density functional theory (DFT) computations, we show that catalytic performances in this field can be impaired by the formation of rotamers before the enantio-determining step. Using DFT, we also demonstrate that these results can help accelerate the process of ligand discovery by providing faster methods to discriminate potential candidates
In order to design improved chiral ruthenium catalysts for asymmetric olefin metathesis,enantiomeric...
The mechanism of enantioselectivity in the asymmetric Ru-catalyzed metathesis of olefins is investig...
The synthesis of Ru-based catalysts, presenting saturated chiral C 2 symmetric (3, 5) and C 1 symmet...
The development of highly efficient enantioselective olefin metathesis catalysts is a significant ch...
International audienceThe development of highly efficient enantioselective olefin metathesis catalys...
An expedient access to the first optically pure ruthenium complexes containing C1-symmetric cyclic (...
International audienceAn expedient access to the first optically pure ruthenium complexes containing...
In order to design improved chiral ruthenium catalysts for asymmetric olefin metathesis, enantiomeri...
The synthesis of Ru-based catalysts, presenting saturated chiral C2 symmetric (3, 5) and C1 symmetri...
In order to design improved chiral ruthenium catalysts for asymmetric olefin metathesis,enantiomeric...
The mechanism of enantioselectivity in the asymmetric Ru-catalyzed metathesis of olefins is investig...
The synthesis of Ru-based catalysts, presenting saturated chiral C 2 symmetric (3, 5) and C 1 symmet...
The development of highly efficient enantioselective olefin metathesis catalysts is a significant ch...
International audienceThe development of highly efficient enantioselective olefin metathesis catalys...
An expedient access to the first optically pure ruthenium complexes containing C1-symmetric cyclic (...
International audienceAn expedient access to the first optically pure ruthenium complexes containing...
In order to design improved chiral ruthenium catalysts for asymmetric olefin metathesis, enantiomeri...
The synthesis of Ru-based catalysts, presenting saturated chiral C2 symmetric (3, 5) and C1 symmetri...
In order to design improved chiral ruthenium catalysts for asymmetric olefin metathesis,enantiomeric...
The mechanism of enantioselectivity in the asymmetric Ru-catalyzed metathesis of olefins is investig...
The synthesis of Ru-based catalysts, presenting saturated chiral C 2 symmetric (3, 5) and C 1 symmet...