Add to ORKGThe ongoing COVID-19 pandemic has had great societal and health consequences. Despite the availability of vaccines, infection rates remain high due to immune evasive Omicron sublineages. Broad-spectrum antivirals are needed to safeguard against emerging variants and future pandemics. We used messenger RNA (mRNA) display under a reprogrammed genetic code to find a spike-targeting macrocyclic peptide that inhibits SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) Wuhan strain infection and pseudoviruses containing spike proteins of SARS-CoV-2 variants or related sarbecoviruses. Structural and bioinformatic analyses reveal a conserved binding pocket between the receptor-binding domain, N-terminal domain, and S2 region, distal to the...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a global pandemic causi...
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) has caused worldwide panic during 2020. T...
Antivirals that specifically target SARS-CoV-2 are needed to control the COVID-19 pandemic. The main...
The ongoing COVID-19 pandemic has had great societal and health consequences. Despite the availabili...
Recent advances in peptide research revolutionized therapeutic discoveries for various infectious di...
The continuous and rapid spread of the COVID-19 pandemic has emphasized the need to seek new therape...
A novel severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) has been identifi...
Macrocyclic peptides are attractive for their favourable drug-like properties, bridging the gap betw...
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently availab...
Drug repurposing for COVID-19 has several potential benefits including shorter development time, red...
The SARS-CoV-2 viral spike protein S receptor-binding domain (S-RBD) binds ACE2 on host cells to ini...
The unprecedented pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is th...
New pathogens responsible for novel human disease outbreaks in the last two decades are mainly the r...
The outbreak of COVID-19 has now become a global pandemic and it continues to spread rapidly worldwi...
Abstract Background and objective Coronavirus disease (COVID-19) is an ongoing pandemic caused by se...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a global pandemic causi...
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) has caused worldwide panic during 2020. T...
Antivirals that specifically target SARS-CoV-2 are needed to control the COVID-19 pandemic. The main...
The ongoing COVID-19 pandemic has had great societal and health consequences. Despite the availabili...
Recent advances in peptide research revolutionized therapeutic discoveries for various infectious di...
The continuous and rapid spread of the COVID-19 pandemic has emphasized the need to seek new therape...
A novel severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) has been identifi...
Macrocyclic peptides are attractive for their favourable drug-like properties, bridging the gap betw...
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently availab...
Drug repurposing for COVID-19 has several potential benefits including shorter development time, red...
The SARS-CoV-2 viral spike protein S receptor-binding domain (S-RBD) binds ACE2 on host cells to ini...
The unprecedented pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is th...
New pathogens responsible for novel human disease outbreaks in the last two decades are mainly the r...
The outbreak of COVID-19 has now become a global pandemic and it continues to spread rapidly worldwi...
Abstract Background and objective Coronavirus disease (COVID-19) is an ongoing pandemic caused by se...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a global pandemic causi...
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) has caused worldwide panic during 2020. T...
Antivirals that specifically target SARS-CoV-2 are needed to control the COVID-19 pandemic. The main...