Type 1 diabetes is an autoimmune disease characterized by destruction of insulin-producing cells with the islets of Langerhans (islets). Clinical islet transplantation is a therapy where islets from a deceased donor are transplanted in the liver of type 1 diabetic patients to restore their blood glucose levels. This leads to a reduced use or even absence of insulin injections by patients. However, the liver is a suboptimal transplantation site leading to loss of islets and suboptimal long-term effects. This thesis investigated the development of a medical implant that can be used to transplant islets to sites other than the liver. Elaborative evaluation of implant design and cell packing have resulted in an implant that consists of so-calle...
Type-1 diabetes (T1D) is a chronic metabolic autoimmune disease where the patient\u27s immune system...
Islet encapsulation in membrane-based devices could allow for transplantation of donor islet tissue ...
Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patien...
Type 1 diabetes is an autoimmune disease characterized by destruction of insulin-producing cells wit...
Type 1 diabetes is an autoimmune disease in which the immune system destroys the insulin producing ß...
Type one diabetes affects 542’000 children per year worldwide and heavily worsens the quality of lif...
Encapsulating, or immunoisolating, insulin-secreting cells within implantable, semipermeable membran...
The restoration of euglycemia after intraportal islet transplantation remains short-lived, requires ...
Intraportal pancreatic islet transplantation is a promising therapy for type 1 diabetes, but the liv...
Background: Type-1 diabetes is caused by autoimmune destruction of insulin-producing B-cells in the ...
Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic islets and is a growing ...
Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patien...
Diabetes mellitus is a global pandemic affecting to more than 500 million people worldwide, with Ty...
Thesis: S.M. in the Concentration of Mechanical Engineering, Harvard-MIT Program in Health Sciences ...
Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patien...
Type-1 diabetes (T1D) is a chronic metabolic autoimmune disease where the patient\u27s immune system...
Islet encapsulation in membrane-based devices could allow for transplantation of donor islet tissue ...
Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patien...
Type 1 diabetes is an autoimmune disease characterized by destruction of insulin-producing cells wit...
Type 1 diabetes is an autoimmune disease in which the immune system destroys the insulin producing ß...
Type one diabetes affects 542’000 children per year worldwide and heavily worsens the quality of lif...
Encapsulating, or immunoisolating, insulin-secreting cells within implantable, semipermeable membran...
The restoration of euglycemia after intraportal islet transplantation remains short-lived, requires ...
Intraportal pancreatic islet transplantation is a promising therapy for type 1 diabetes, but the liv...
Background: Type-1 diabetes is caused by autoimmune destruction of insulin-producing B-cells in the ...
Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic islets and is a growing ...
Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patien...
Diabetes mellitus is a global pandemic affecting to more than 500 million people worldwide, with Ty...
Thesis: S.M. in the Concentration of Mechanical Engineering, Harvard-MIT Program in Health Sciences ...
Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patien...
Type-1 diabetes (T1D) is a chronic metabolic autoimmune disease where the patient\u27s immune system...
Islet encapsulation in membrane-based devices could allow for transplantation of donor islet tissue ...
Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in patien...