Recent advances in biomaterials and 3D printing/culture methods enable various tissue-engineered tumor models. However, it is still challenging to achieve native tumor-like characteristics due to lower cell density than native tissues and prolonged culture duration for maturation. Here, we report a new method to create tumoroids with a mechanically active tumor-stroma interface at extremely high cell density. This method, named “inkjet-printed morphogenesis” (iPM) of the tumor-stroma interface, is based on a hypothesis that cellular contractile force can significantly remodel the cell-laden polymer matrix to form densely-packed tissue-like constructs. Thus, differential cell-derived compaction of tumor cells and cancer-associated fibroblast...
Current tissue engineering techniques have various drawbacks: they often incorporate uncontrolled an...
A challenge for tissue engineering is producing three-dimensional (3D), vascularized cellular constr...
A hybrid 3D bioprinting approach using porous microscaffolds and extrusion-based printing method is ...
In vitro cancer 3D models are valuable tools to provide mechanistic insight into solid tumor growth,...
Successful tissue engineering requires the generation of human scale implants that mimic the structu...
Tumor cells evolve in a complex and heterogeneous environment composed of different cell types and a...
Cells in their natural 3D environment experience a variety of topographies of the extracellular matr...
One of the major challenges encountered in engineering complex tissues in vitro is to increase level...
Extrusion bioprinting is a relevant 3D technology to create biological systems in regenerative medic...
Bioprinting allows the fabrication of living constructs with custom-made architectures by spatially ...
Three-dimensional (3D) printing offers versatile possibilities for adapting the structural parameter...
The National Cancer Institute estimates that approximately 40% of men and women will be diagnosed wi...
Building human tissues via 3D cell printing technology has received particular attention due to its ...
Drop-on-demand inkjet printing has opened new opportunities to develop faster, smaller and cheaper b...
Current tissue engineering techniques have various drawbacks: they often incorporate uncontrolled an...
Current tissue engineering techniques have various drawbacks: they often incorporate uncontrolled an...
A challenge for tissue engineering is producing three-dimensional (3D), vascularized cellular constr...
A hybrid 3D bioprinting approach using porous microscaffolds and extrusion-based printing method is ...
In vitro cancer 3D models are valuable tools to provide mechanistic insight into solid tumor growth,...
Successful tissue engineering requires the generation of human scale implants that mimic the structu...
Tumor cells evolve in a complex and heterogeneous environment composed of different cell types and a...
Cells in their natural 3D environment experience a variety of topographies of the extracellular matr...
One of the major challenges encountered in engineering complex tissues in vitro is to increase level...
Extrusion bioprinting is a relevant 3D technology to create biological systems in regenerative medic...
Bioprinting allows the fabrication of living constructs with custom-made architectures by spatially ...
Three-dimensional (3D) printing offers versatile possibilities for adapting the structural parameter...
The National Cancer Institute estimates that approximately 40% of men and women will be diagnosed wi...
Building human tissues via 3D cell printing technology has received particular attention due to its ...
Drop-on-demand inkjet printing has opened new opportunities to develop faster, smaller and cheaper b...
Current tissue engineering techniques have various drawbacks: they often incorporate uncontrolled an...
Current tissue engineering techniques have various drawbacks: they often incorporate uncontrolled an...
A challenge for tissue engineering is producing three-dimensional (3D), vascularized cellular constr...
A hybrid 3D bioprinting approach using porous microscaffolds and extrusion-based printing method is ...