Serum antibody response to canine distemper Virus vaccines in beagle dogs

The three commercial triple CDV vaccines used for vaccination differ by the Virus strain and the method of production. The immunogenicity of these vaccines was studied in beagle dogs under experimental conditions using neutralizing antibodytiters as the measure.Differences in antibody responses were detected between the three distemper vaccines. Rockborn strain produced in canine cells (vaccine 1) induced on average the highest titers and smallest variance of serum neutra1i7ing antibodies betweenvaccine groups. There was also a significant difference between the 2 Onderstepoort strains (vaccine 2 and 3) inducing CDV antibodies in dogs one month after first vaccination indicating difference in antigenicity between the vaccines