Tumor necrosis factor (TNF) is a pro-inflammatory cytokine that has a straight relationship with tissue destruction in the pathogenesis of periodontitis. Inhibitory effects of TNF production have been attributed to spironolactone. The aim of this study was to evaluate the effect of spironolactone on the pathogenesis of ligature-induced alveolar bone loss in rats. Experimental periodontitis was induced in 38 Wistar rats by ligature placement in the left second maxillary molar. The contra-lateral maxillary molar served as intragroup control. Animals were randomly divided into 4 groups and treated with spironolactone (50, 100, 200 mg·kg-1) or saline. Morphometrical registration of maxillary alveolar bone was performed after 28 days of e...
Periodontitis is the most common lytic bone disease and one of the first clinical manifestations of ...
Periodontitis is a disease characterized by leukocyte influx, loss of connective tissue and bone res...
Objectives The first cause of tooth loss in developed countries is periodontitis and mostly occurs i...
AbstractObjectiveTo evaluate the effect of different concentrations of inhaled budesonide on secreti...
Background. The potent anti-inflammatory and immunosuppressive properties of glucocorticoids (GCs) m...
Periodontitis is an inflammatory disease characterized by dysbiosis and alveolar bone resorption (AB...
Periodontitis is a chronic disease characterized by bone loss and inflammatory changes. We studied t...
Chronic inflammatory conditions have been associated with pathological outcomes, resulting in events...
We sought to better characterize the progression of periodontal tissue breakdown in rats induced by ...
Background: It appears there are no studies evaluating the influence of the bisphosphonate tiludroni...
Background: This study assesses the effects of topical sodium alendronate (SA) as an adjuvant to the...
Background: It appears there are no studies evaluating the influence of the bisphosphonate tiludron...
Simvastatin is a cholesterol-lowering drug whose pleiotropic effects may have therapeutic impact in ...
AbstractObjectiveTo evaluate the effect of different concentrations of inhaled budesonide on secreti...
Objective: The aim of this study was to evaluate the effects of gliclazide on oxidative stress, infl...
Periodontitis is the most common lytic bone disease and one of the first clinical manifestations of ...
Periodontitis is a disease characterized by leukocyte influx, loss of connective tissue and bone res...
Objectives The first cause of tooth loss in developed countries is periodontitis and mostly occurs i...
AbstractObjectiveTo evaluate the effect of different concentrations of inhaled budesonide on secreti...
Background. The potent anti-inflammatory and immunosuppressive properties of glucocorticoids (GCs) m...
Periodontitis is an inflammatory disease characterized by dysbiosis and alveolar bone resorption (AB...
Periodontitis is a chronic disease characterized by bone loss and inflammatory changes. We studied t...
Chronic inflammatory conditions have been associated with pathological outcomes, resulting in events...
We sought to better characterize the progression of periodontal tissue breakdown in rats induced by ...
Background: It appears there are no studies evaluating the influence of the bisphosphonate tiludroni...
Background: This study assesses the effects of topical sodium alendronate (SA) as an adjuvant to the...
Background: It appears there are no studies evaluating the influence of the bisphosphonate tiludron...
Simvastatin is a cholesterol-lowering drug whose pleiotropic effects may have therapeutic impact in ...
AbstractObjectiveTo evaluate the effect of different concentrations of inhaled budesonide on secreti...
Objective: The aim of this study was to evaluate the effects of gliclazide on oxidative stress, infl...
Periodontitis is the most common lytic bone disease and one of the first clinical manifestations of ...
Periodontitis is a disease characterized by leukocyte influx, loss of connective tissue and bone res...
Objectives The first cause of tooth loss in developed countries is periodontitis and mostly occurs i...