peer reviewedBackground: In vitro maturation of immature testicular tissue (ITT) cryopreserved for fertility preservation is a promising fertility restoration strategy. Organotypic tissue culture proved successful in mice, leading to live births. In larger mammals, including humans, efficiently reproducing spermatogenesis ex vivo remains challenging. With advances in biomaterials technology, culture systems are becoming more complex to better mimic in vivo conditions. Along with improving culture media components, optimizing physical culture conditions (e.g., tissue perfusion, oxygen diffusion) also needs to be considered. Recent studies in mice showed that by using silicone-based hybrid culture systems, the efficiency of spermatogenesis ca...
Adult survivors of childhood cancer can suffer from infertility due to gonadotoxic treatments receiv...
Male infertility has received vast attention in recent years and has no clear etiology in almost 40%...
The studies presented in this thesis were designed to establish, examine and characterize a porcine ...
BACKGROUND: In vitro maturation of immature testicular tissue (ITT) cryopreserved for fertility pres...
STUDY QUESTION: Is an organotypic culture system able to provide the appropriate testicular microenv...
The studies presented in this thesis were designed to identify, examine, and manipulate potential fa...
Cryopreservation of immature testicular tissue (ITT) prior to chemo/radiotherapy is now ethically ac...
In vitro systems to model the testicular microenvironment are required to study physiology and patho...
STUDY QUESTION: Can the organ culture method be applied to both fresh and cryopreserved human (pre)p...
Cryopreservation of prepubertal testicular tissue is the only option to preserve the fertility of yo...
While in mice various studies have described the completion of spermatogenesis in vitro using either...
International audienceSTUDY QUESTION: Do freezing and in vitro culture procedures enhance the expres...
AbstractThe objective of this study was to establish a porcine spermatogonial germ cell (pSGC) line ...
Testis development and function involve multiple cell types and require complex cellular interaction...
Canine testes thin section culture Testes tissue culture systems would provide a tool to elucidate s...
Adult survivors of childhood cancer can suffer from infertility due to gonadotoxic treatments receiv...
Male infertility has received vast attention in recent years and has no clear etiology in almost 40%...
The studies presented in this thesis were designed to establish, examine and characterize a porcine ...
BACKGROUND: In vitro maturation of immature testicular tissue (ITT) cryopreserved for fertility pres...
STUDY QUESTION: Is an organotypic culture system able to provide the appropriate testicular microenv...
The studies presented in this thesis were designed to identify, examine, and manipulate potential fa...
Cryopreservation of immature testicular tissue (ITT) prior to chemo/radiotherapy is now ethically ac...
In vitro systems to model the testicular microenvironment are required to study physiology and patho...
STUDY QUESTION: Can the organ culture method be applied to both fresh and cryopreserved human (pre)p...
Cryopreservation of prepubertal testicular tissue is the only option to preserve the fertility of yo...
While in mice various studies have described the completion of spermatogenesis in vitro using either...
International audienceSTUDY QUESTION: Do freezing and in vitro culture procedures enhance the expres...
AbstractThe objective of this study was to establish a porcine spermatogonial germ cell (pSGC) line ...
Testis development and function involve multiple cell types and require complex cellular interaction...
Canine testes thin section culture Testes tissue culture systems would provide a tool to elucidate s...
Adult survivors of childhood cancer can suffer from infertility due to gonadotoxic treatments receiv...
Male infertility has received vast attention in recent years and has no clear etiology in almost 40%...
The studies presented in this thesis were designed to establish, examine and characterize a porcine ...