The pivotal role of Pejvakin (DFNB59) protein in hearing loss in humans

Objective The protein pejvakin, also known as DFNB59, is largely expressed in the inner ear, and other organs like testis (highest concentration), liver, brain, lungs, eyes, kidneys, and intestinal tissues. and is essential for hearing [1]. Pejvakin belongs to the gasdermin family of proteins that mediate pyroapoptosis in vertebrates. Gasdermin family comprises conserved affecter N-terminal domain that causes oligomerization, to form channels or pores in plasma membrane [2]. The functional proteins of Gasdermin family have immunoregulatory, cellular growth, and host immune defence [3]. Gasdermin family of protein seem homologous with respect to pore forming N terminal affecter end, this applies to pejvakin protein also [4]. There are many unanswered questions in the pathway, interaction, cellular mechanism of this protein [5]. Methods This presentation evaluates the role of pejvakin (DFNB59) protein in the development of post-lingual deafness in the light of extant evidence and uses this protein as a case-study protein in molecular mechanisms that lead to deafness in human beings. Results My presentation explicates the behavior of ciliary rootlet protein pejvakin (DFNB59) with homology to gasdermin family in the light of available genetic, molecular, biochemical, and computational evidence.