Exercise Training Induced ERK1/2 Expression in Bone

Osteoporosis is bone metabolic disorder that can decrease quality of life. It is the reason why that this study on the factors on bone metabolism urgently conducted. The research was conducted to describe the role of exercise training on bone metabolism on rat ovariectomized by using cell and molecular approach. This research was purely experiment research that was carried out to prove that exercise training can increase extra cellular signal regulated kinase (ERK1/2) and it correlation with calcium. Design of the research “The Randomized Posttest only. Control Group Design”. The unit of experimental was female Sprague Dawly Rat, 2,5 months and divided in three group A) Ovariectomized (O); B) O + exercise training (ET)and C) Ovariectomized calcium supplement (CS). Exercise training as independent variable and ERK1/2 expression was dependent variable. ERK1/2 was measured by using ELISA, while and calcium level measured by using SSA. The data was analysis by using ANOVA. The result of this research showed that ERK1/2 expression of the exercise training were higher (1,861) than the control group (1,031) α 0.005 and calcium level were not different in all group. It can be concluded that exercise training can decrease ERK1/2 expression but no change on level of calciu