Silencing of endogenous retroviruses (ERVs) is largely mediated by repressive chromatin modifications H3K9me3 and DNA methylation. On ERVs, these modifications are mainly deposited by the histone methyltransferase Setdb1 and by the maintenance DNA methyltransferase Dnmt1 . Knock-out of either Setdb1 or Dnmt1 leads to ERV de-repression in various cell types. However, it is currently not known if H3K9me3 and DNA methylation depend on each other for ERV silencing. Here we show that conditional knock-out of Setdb1 in mouse embryonic endoderm results in ERV de-repression in visceral endoderm (VE) descendants and does not occur in definitive endoderm (DE). Deletion of Setdb1 in VE progenitors results in loss of H3K9me3 and reduced DNA methylation...
More than forty per cent of the mammalian genome is derived from retroelements, of which about one-q...
International audienceBackground: Transposable elements are often the targets of repressive epigenet...
<div><p>Retrotransposition of endogenous retroviruses (ERVs) poses a substantial threat to genome st...
Silencing of endogenous retroviruses (ERVs) is largely mediated by repressive chromatin modification...
Background: Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutat...
BACKGROUND: Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutat...
SummaryDNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) play important roles in sile...
DNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) play important roles in silencing o...
Endogenous retroviruses (ERVs) are found in genomes of all higher eukaryotes. As retrotransposition ...
During mammalian development, DNA methylation patterns need to be reset in primordial germ cells (PG...
Background: Endogenous retroviruses (ERVs) are parasitic sequences whose derepressi...
During mammalian development, DNA methylation patterns need to be reset in primordial germ cells (PG...
Retrotransposons, such as endogenous retroviruses (ERVs), have colonized the genomes of all metazoan...
Transcription of endogenous retroviruses (ERVs) is inhibited by de novo DNA methylation during gamet...
Endogenous retroviruses (ERVs) undergo de novo DNA methylation during the first few days of mammalia...
More than forty per cent of the mammalian genome is derived from retroelements, of which about one-q...
International audienceBackground: Transposable elements are often the targets of repressive epigenet...
<div><p>Retrotransposition of endogenous retroviruses (ERVs) poses a substantial threat to genome st...
Silencing of endogenous retroviruses (ERVs) is largely mediated by repressive chromatin modification...
Background: Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutat...
BACKGROUND: Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutat...
SummaryDNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) play important roles in sile...
DNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) play important roles in silencing o...
Endogenous retroviruses (ERVs) are found in genomes of all higher eukaryotes. As retrotransposition ...
During mammalian development, DNA methylation patterns need to be reset in primordial germ cells (PG...
Background: Endogenous retroviruses (ERVs) are parasitic sequences whose derepressi...
During mammalian development, DNA methylation patterns need to be reset in primordial germ cells (PG...
Retrotransposons, such as endogenous retroviruses (ERVs), have colonized the genomes of all metazoan...
Transcription of endogenous retroviruses (ERVs) is inhibited by de novo DNA methylation during gamet...
Endogenous retroviruses (ERVs) undergo de novo DNA methylation during the first few days of mammalia...
More than forty per cent of the mammalian genome is derived from retroelements, of which about one-q...
International audienceBackground: Transposable elements are often the targets of repressive epigenet...
<div><p>Retrotransposition of endogenous retroviruses (ERVs) poses a substantial threat to genome st...