The opportunistic human pathogen Pseudomonas aeruginosa expresses numerous acute virulence factors in the initial phase of infection, and during long-term colonization it undergoes adaptations that optimize survival in the human host. Adaptive changes that often occur during chronic infection give rise to rugose small colony variants (RSCVs), which are hyper-biofilm-forming mutants that commonly possess mutations that increase production of the biofilm-promoting secondary messenger cyclic di-GMP (c-di-GMP). We show that RSCVs display a decreased production of acute virulence factors as a direct result of elevated c-di-GMP content. Overproduction of c-di-GMP causes a decrease in the transcription of virulence factor genes that are regulated ...
Most bacteria can form multicellular communities called biofilms on biotic and abiotic surfaces. Thi...
Vfr, a transcription factor homologous to the Escherichia coli cyclic AMP (cAMP) receptor protein (C...
Multiple virulence systems in the opportunistic pathogen Pseudomonas aeruginosa are regulated by the...
The opportunistic human pathogen Pseudomonas aeruginosa expresses numerous acute virulence factors i...
The opportunistic human pathogen Pseudomonas aeruginosa expresses numerous acute virulence factors i...
Vfr is a global regulator of virulence factor expression in the human pathogen Pseudomonas aeruginos...
The transcription factor AmrZ regulates genes important for P. aeruginosa virulence, including type ...
Vfr is a global regulator of virulence factor expression in the human pathogen Pseudomonas aeruginos...
Cyclic AMP (cAMP) is a signaling molecule that is involved in the regulation of multiple virulence s...
Multiple virulence systems in the opportunistic pathogen Pseudomonas aeruginosa are regulated by the...
Cyclic-di-GMP (c-di-GMP) is an intracellular secondary messenger which controls the biofilm life cyc...
The opportunistic human pathogen Pseudomonas aeruginosa is able to survive under a variety of often ...
ABSTRACT The signaling nucleotide cyclic diguanylate (c-di-GMP) regulates the transition between mot...
Cyclic AMP (cAMP) is a signaling molecule that is involved in the regulation of multiple virulence s...
Cyclic-di-GMP (c-di-GMP) is an intracellular secondary messenger which controls the biofilm life cyc...
Most bacteria can form multicellular communities called biofilms on biotic and abiotic surfaces. Thi...
Vfr, a transcription factor homologous to the Escherichia coli cyclic AMP (cAMP) receptor protein (C...
Multiple virulence systems in the opportunistic pathogen Pseudomonas aeruginosa are regulated by the...
The opportunistic human pathogen Pseudomonas aeruginosa expresses numerous acute virulence factors i...
The opportunistic human pathogen Pseudomonas aeruginosa expresses numerous acute virulence factors i...
Vfr is a global regulator of virulence factor expression in the human pathogen Pseudomonas aeruginos...
The transcription factor AmrZ regulates genes important for P. aeruginosa virulence, including type ...
Vfr is a global regulator of virulence factor expression in the human pathogen Pseudomonas aeruginos...
Cyclic AMP (cAMP) is a signaling molecule that is involved in the regulation of multiple virulence s...
Multiple virulence systems in the opportunistic pathogen Pseudomonas aeruginosa are regulated by the...
Cyclic-di-GMP (c-di-GMP) is an intracellular secondary messenger which controls the biofilm life cyc...
The opportunistic human pathogen Pseudomonas aeruginosa is able to survive under a variety of often ...
ABSTRACT The signaling nucleotide cyclic diguanylate (c-di-GMP) regulates the transition between mot...
Cyclic AMP (cAMP) is a signaling molecule that is involved in the regulation of multiple virulence s...
Cyclic-di-GMP (c-di-GMP) is an intracellular secondary messenger which controls the biofilm life cyc...
Most bacteria can form multicellular communities called biofilms on biotic and abiotic surfaces. Thi...
Vfr, a transcription factor homologous to the Escherichia coli cyclic AMP (cAMP) receptor protein (C...
Multiple virulence systems in the opportunistic pathogen Pseudomonas aeruginosa are regulated by the...