Towards understanding of PRC2 binding to RNA

Polycomb repressive complex 2 (PRC2) and its methylation of histone 3 at lysine 27 (H3K27me3) play a crucial role in epigenetic regulation of normal development and malignancy. Several factors regulate the recruitment of PRC2 and affects its chromatin modification function. Over the past years, emerging discoveries have portrayed the association of RNA (protein-coding and non-coding) with PRC2 as a critical factor in understanding PRC2 function. With PRC2 being a macromolecular complex of interest in development and diseases, further studies are needed to relate the rapidly evolving PRC2:RNA biology in that scenario. In this review, we summarize the current understanding of different modes of RNA binding by PRC2, and further discuss perspectives, key questions and therapeutic applications of PRC2 binding to RNAs.Ministry of Education (MOE)National Medical Research Council (NMRC)This study is supported by the National Medical Research Council (NMRC) Grants NMRC/CIRG/1343/2012 (W.-J. Chng), NMRC/BNIG/2021/2014 (J. Yan), the RNA Biology Center at CSI Singapore, NUS, as part of funding under the Singapore Ministry of Education’s Tier 3 grant MOE2014-T3-1-006, and the Singapore Ministry of Education Academic Research Fund Tier 2 grant MOE2015-T2-2-119. W.-J. Chng. was also supported by the NMRC Clinician Scientist Investigator Award and Singapore Translational Research (STaR) Award