A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus

Adult neurogenesis in the dentate gyrus plays a role in adaptive brain functions such as memory formation. Adding new neurons to a specific locus of a neural circuit with functional needs is an efficient way to achieve such an adaptive function. However, it is unknown whether neurogenesis is linked to local functional demands potentially specified by the activity of neuronal circuits. By examining the distribution of neurogenesis and different types of neuronal activity in the dentate gyrus of freely moving adult rats, we find that neurogenesis is positionally associated with active excitatory neurons, some of which show place-cell activity, but is positionally dissociated from a type of interneuron with high-burst tendency. Our finding suggests that the behaviorally relevant activity of excitatory-inhibitory neuronal circuits can define a microenvironment stimulating/inhibiting neurogenesis. Such local regulation of neurogenesis may contribute to strategic recruitment of new neurons to modify functionally relevant neural circuits.Ministry of Education (MOE)National Medical Research Council (NMRC)Published versionThis work was supported by the Ministry of Education of Singapore (MOE2015-T2-2-035 and MOE2017-T3-1-002), NIMBELS (NIM/02/2016), National Medical Research Council of Singapore (NMRC/OFIRG/0046/2017), European Research Council (208132), Research Council of Norway (FRIBIO, 197184), James S. McDonnell Foundation (to A.T.), and Human Frontiers Science Programme (to M.U.)