This paper explains Malaysia-US relations in terms of national interests derived from the the nature of the Malaysian political economy and the salience of Islam in Malay(sian) politics as they interact with US foreign policy derived from distinct US grand strategies. The paper compares Malaysia's responses to the US under the Clinton and the first George W Bush Administrations in terms of the following: (a) instances of cooperation and non-cooperation on key US initiatives; (b) pursuit of alternative economic and defence/security relationships; and (c) construction of alternative discourses and coalitions aimed at challenging US initiatives and its hegemony more broadly. Malaysia's responses to the US can be summed up in the phrase, 'rejec...