Add to ORKGThe synthesis and characterisation of a novel Pt(IV) monocarboxy precursor complex c,c,t-[Pt(DACH)(Ox)(OEt)(Suc)], which can be employed to synthesise mono functionalised Pt(IV) oxaliplatin-based complexes is reported. Reaction of c,c,t-[Pt(DACH)(Ox)(OEt)(Suc)] with a tumour penetrating peptide, TPP, afforded the corresponding novel monofunctionalised Pt(IV) peptide conjugate c,c,t-[Pt(DACH)(Ox)(OEt)(SucTPP)] in high purity. Conjugation of TPP to c,c,t-[Pt(DACH)(Ox)(OEt)(Suc)] was demonstrated to ameliorate its inherent cytotoxicity fifteen fold in the Pt sensitive HCT116 colorectal cancer cell line and two fold in the relatively resistant HT29 colorectal cancer cell line
Two new Pt(II)-pyrophosphato complexes containing the carrier ligands cis-1,3-diaminocyclohexane (c...
The cytotoxic cisplatin effect is exploited in the treatment of solid tumors since four decades. Des...
The azide-functionalized PtIV complex (OC-6–34)-chlorido(cyclobutane-1,1′-dicarboxylato)(cyclohexane...
The synthesis and characterisation of a novel Pt(IV) monocarboxy precursor complex c,c,t-[Pt(DACH)(O...
Novel Pt(iv) tumour penetrating peptide (TPP) conjugates are reported. They are the first example of...
The first Pt(IV) derivative of oxaliplatin carrying a ligand for TSPO (the 18-kDa mitochondrial tran...
The coordination of biologically active moieties to the axial positions of Pt(IV) derivatives of Pt(...
Oxalate 1,2-diaminocyclohexane platinum (oxaliplatin(R)), a successfully employed platinum compound ...
We describe herein a novel Pt(IV)-acetamidato complex as a result of the one-pot reaction between ci...
We describe herein a novel Pt(iv)-acetamidato complex as a result of the one-pot reaction between ci...
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Six platinum(IV) compounds derived from an...
Cancer is one of the leading causes of death worldwide and due to an ageing and growing population, ...
With the aim to obtain dual acting drugs able to target both nuclear DNA and mitochondria, Pt(iv) ki...
Increasing the specificity of cancer therapy, and thereby decreasing damage to normal cells, require...
A series of novel symmetrically and unsymmetrically coordinated platinum(IV) complexes with monodent...
Two new Pt(II)-pyrophosphato complexes containing the carrier ligands cis-1,3-diaminocyclohexane (c...
The cytotoxic cisplatin effect is exploited in the treatment of solid tumors since four decades. Des...
The azide-functionalized PtIV complex (OC-6–34)-chlorido(cyclobutane-1,1′-dicarboxylato)(cyclohexane...
The synthesis and characterisation of a novel Pt(IV) monocarboxy precursor complex c,c,t-[Pt(DACH)(O...
Novel Pt(iv) tumour penetrating peptide (TPP) conjugates are reported. They are the first example of...
The first Pt(IV) derivative of oxaliplatin carrying a ligand for TSPO (the 18-kDa mitochondrial tran...
The coordination of biologically active moieties to the axial positions of Pt(IV) derivatives of Pt(...
Oxalate 1,2-diaminocyclohexane platinum (oxaliplatin(R)), a successfully employed platinum compound ...
We describe herein a novel Pt(IV)-acetamidato complex as a result of the one-pot reaction between ci...
We describe herein a novel Pt(iv)-acetamidato complex as a result of the one-pot reaction between ci...
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Six platinum(IV) compounds derived from an...
Cancer is one of the leading causes of death worldwide and due to an ageing and growing population, ...
With the aim to obtain dual acting drugs able to target both nuclear DNA and mitochondria, Pt(iv) ki...
Increasing the specificity of cancer therapy, and thereby decreasing damage to normal cells, require...
A series of novel symmetrically and unsymmetrically coordinated platinum(IV) complexes with monodent...
Two new Pt(II)-pyrophosphato complexes containing the carrier ligands cis-1,3-diaminocyclohexane (c...
The cytotoxic cisplatin effect is exploited in the treatment of solid tumors since four decades. Des...
The azide-functionalized PtIV complex (OC-6–34)-chlorido(cyclobutane-1,1′-dicarboxylato)(cyclohexane...