Local antibiotic therapy is increasingly being recognised for its role in preventing and treating orthopaedic device-related infection (ODRI). A bioresorbable, injectable gentamicin-loaded hydrogel has been developed to deliver local antibiotics at the time of surgery with potential for both prevention and treatment of ODRI. In a prophylaxis model, the antibiotic hydrogel was compared with systemic perioperative antibiotic prophylaxis alone in twelve sheep (six per group) at the time of intramedullary (IM) nail insertion to the tibia, which was inoculated with methicillin-sensitive Staphylococcus aureus (MSSA). In a treatment model of single-stage revision surgery, adjunctive antibiotic-loaded hydrogel was compared with systemic antibiotics...
ABSTRACT: Infected bone defects and osteomyelitis are encountered fre-quently in trauma cases. Curre...
Local antibiotic delivery strategies have been increasingly employed for the prevention of fracture-...
OBJECTIVE: To evaluate biocompatibility of biodegradable sleeves containing antimicrobial agents, de...
Local antibiotic therapy is increasingly being recognised for its role in preventing and treating or...
Local prophylaxis with antibiotic-loaded bone cement is a successful method to prevent post-operativ...
Antibiotic-loaded biomaterials (ALBs) have emerged as a potentially useful adjunctive antimicrobial ...
Infection of orthopedic devices is a major complication in the postsurgical period generating import...
Open fractures are at risk of serious infection and, if infected, require several surgical intervent...
Orthopedic implant infections are a significant clinical problem, with current therapies limited to ...
Open fractures are at risk of serious infection and, if infected, require several surgical intervent...
IntroductionTreatment of open fractures routinely involves multiple surgeries and delayed definitive...
A degradable, poly (lactic-co-glycolic acid) (PLGA), gentamicin-loaded prophylactic coating for hydr...
Despite the use of systemic antibiotic prophylaxis, the surgical fixation of open fractures with ost...
Orthopedic device-related infection (ODRI) is a potentially devastating complication arising from th...
Prevention of fracture-related infection (FRI) remains a substantial challenge in orthopaedic trauma...
ABSTRACT: Infected bone defects and osteomyelitis are encountered fre-quently in trauma cases. Curre...
Local antibiotic delivery strategies have been increasingly employed for the prevention of fracture-...
OBJECTIVE: To evaluate biocompatibility of biodegradable sleeves containing antimicrobial agents, de...
Local antibiotic therapy is increasingly being recognised for its role in preventing and treating or...
Local prophylaxis with antibiotic-loaded bone cement is a successful method to prevent post-operativ...
Antibiotic-loaded biomaterials (ALBs) have emerged as a potentially useful adjunctive antimicrobial ...
Infection of orthopedic devices is a major complication in the postsurgical period generating import...
Open fractures are at risk of serious infection and, if infected, require several surgical intervent...
Orthopedic implant infections are a significant clinical problem, with current therapies limited to ...
Open fractures are at risk of serious infection and, if infected, require several surgical intervent...
IntroductionTreatment of open fractures routinely involves multiple surgeries and delayed definitive...
A degradable, poly (lactic-co-glycolic acid) (PLGA), gentamicin-loaded prophylactic coating for hydr...
Despite the use of systemic antibiotic prophylaxis, the surgical fixation of open fractures with ost...
Orthopedic device-related infection (ODRI) is a potentially devastating complication arising from th...
Prevention of fracture-related infection (FRI) remains a substantial challenge in orthopaedic trauma...
ABSTRACT: Infected bone defects and osteomyelitis are encountered fre-quently in trauma cases. Curre...
Local antibiotic delivery strategies have been increasingly employed for the prevention of fracture-...
OBJECTIVE: To evaluate biocompatibility of biodegradable sleeves containing antimicrobial agents, de...