Multi-Trait Genetic Analysis Identifies Autoimmune Loci Associated with Cutaneous Melanoma
- Liyanage, Upekha E.
- MacGregor, Stuart
- Bishop, D. Timothy
- Shi, Jianxin
- An, Jiyuan
- Ong, Jue Sheng
- Han, Xikun
- Scolyer, Richard A.
- Martin, Nicholas G.
- Medland, Sarah E.
- Byrne, Enda M.
- Green, Adèle C.
- Saw, Robyn P.M.
- Thompson, John F.
- Stretch, Jonathan
- Spillane, Andrew
- Jiang, Yunxuan
- Tian, Chao
- Agee, Michelle
- Aslibekyan, Stella
- Auton, Adam
- Babalola, Elizabeth
- Bell, Robert K.
- Bielenberg, Jessica
- Bryc, Katarzyna
- Bullis, Emily
- Cameron, Briana
- Coker, Daniella
- Cuellar Partida, Gabriel
- Dhamija, Devika
- Das, Sayantan
- Elson, Sarah L.
- Filshtein, Teresa
- Fletez-Brant, Kipper
- Fontanillas, Pierre
- Freyman, Will
- Gandhi, Pooja M.
- Heilbron, Karl
- Hicks, Barry
- Hinds, David A.
- Huber, Karen E.
- Jewett, Ethan M.
- Kleinman, Aaron
- Kukar, Katelyn
- Lin, Keng Han
- Lowe, Maya
- Luff, Marie K.
- McCreight, Jennifer C.
- McIntyre, Matthew H.
- McManus, Kimberly F.
- Micheletti, Steven J.
- Moreno, Meghan E.
- Mountain, Joanna L.
- Mozaffari, Sahar V.
- Nandakumar, Priyanka
- Noblin, Elizabeth S.
- O'Connell, Jared
- Petrakovitz, Aaron A.
- Poznik, G. David
- Shastri, Anjali J.
- Shelton, Janie F.
- Shi, Jingchunzi
- Shringarpure, Suyash
- Tran, Vinh
- Tung, Joyce Y.
- Wang, Xin
- Wang, Wei
- Weldon, Catherine H.
- Wilton, Peter
- Gordon, Scott G.
- Duffy, David L.
- Olsen, Catherine M.
- Whiteman, David C.
- Long, Georgina V.
- Iles, Mark M.
- Landi, Maria Teresa
- Law, Matthew H.
- other, and
DOIAbstract
Genome-wide association studies (GWAS) have identified a number of risk loci for cutaneous melanoma. Cutaneous melanoma shares overlapping genetic risk (genetic correlation) with a number of other traits, including its risk factors such as sunburn propensity. This genetic correlation can be exploited to identify additional cutaneous melanoma risk loci by multitrait analysis of GWAS (MTAG). We used bivariate linkage disequilibrium–score regression score regression to identify traits that are genetically correlated with clinically confirmed cutaneous melanoma and then used publicly available GWAS for these traits in a multitrait analysis of GWAS. Multitrait analysis of GWAS allows GWAS to be combined while accounting for sample overlap and in...
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