Add to ORKGA short, diastereoselective synthesis of homocitric acid lactone is described. The key step is a bioinspired aldol addition to set the stereogenic center in an intermediate that requires only modest oxidation state manipulation to complete the synthesis. This approach enables rapid generation of isotopomers in which carbon and hydrogen can be replaced by heavier nuclei at nearly every position
Organic synthesis allows access complex materials in the context of fine chemicals, pharmaceuticals,...
A stereoselective two-carbon homologation protocol has been developed and applied to the asymmetric ...
Trimethyl (3R)-homocitrate 17, trimethyl (2S,3R)-[2-2H1]-homocitrate 17a and (2R,3R)-[2-2H1]-homocit...
A concise synthesis of homocitric acid lactone was developed to accommodate systematic placement of ...
A concise synthesis of homocitric acid lactone was developed to accommodate systematic placement of ...
The total synthesis of lactone 1 has been described. The convergent asymmetric synthesis relies on t...
The group-selective aldolization/desymmetrization of meso dialdehyde 5 with a borylenolate derived f...
Polyfunctionalised lactones with up to five contiguous stereocentres may be prepared with high stere...
A stereoselective synthesis of threo-γ-hydroxy-β-l-lysine lactone is reported. The threo-amino alcoh...
In this Letter we describe a 12% overall yield synthesis of a model for homoallylic oxygenated alpha...
A stereoselective synthesis of the pentaketide lactone (3R,4S,5S,9S)-3,5,9-trihydroxy-4-methylundeca...
A stereoselective synthesis of the pentaketide lactone (3R,4S,5S,9S)-3,5,9-trihydroxy-4-methylundeca...
An enantioselective total synthesis of the natural amino acid (2S,4R,5R)-4,5-di-hydroxy-pipecolic ac...
This thesis describes the development of chiral auxiliary based methodologies for the asymmetric syn...
Trimethyl (3R)-homocitrate 17, trimethyl (2S,3R)-[2-2H1]-homocitrate 17a and (2R,3R)-[2-2H1]-homocit...
Organic synthesis allows access complex materials in the context of fine chemicals, pharmaceuticals,...
A stereoselective two-carbon homologation protocol has been developed and applied to the asymmetric ...
Trimethyl (3R)-homocitrate 17, trimethyl (2S,3R)-[2-2H1]-homocitrate 17a and (2R,3R)-[2-2H1]-homocit...
A concise synthesis of homocitric acid lactone was developed to accommodate systematic placement of ...
A concise synthesis of homocitric acid lactone was developed to accommodate systematic placement of ...
The total synthesis of lactone 1 has been described. The convergent asymmetric synthesis relies on t...
The group-selective aldolization/desymmetrization of meso dialdehyde 5 with a borylenolate derived f...
Polyfunctionalised lactones with up to five contiguous stereocentres may be prepared with high stere...
A stereoselective synthesis of threo-γ-hydroxy-β-l-lysine lactone is reported. The threo-amino alcoh...
In this Letter we describe a 12% overall yield synthesis of a model for homoallylic oxygenated alpha...
A stereoselective synthesis of the pentaketide lactone (3R,4S,5S,9S)-3,5,9-trihydroxy-4-methylundeca...
A stereoselective synthesis of the pentaketide lactone (3R,4S,5S,9S)-3,5,9-trihydroxy-4-methylundeca...
An enantioselective total synthesis of the natural amino acid (2S,4R,5R)-4,5-di-hydroxy-pipecolic ac...
This thesis describes the development of chiral auxiliary based methodologies for the asymmetric syn...
Trimethyl (3R)-homocitrate 17, trimethyl (2S,3R)-[2-2H1]-homocitrate 17a and (2R,3R)-[2-2H1]-homocit...
Organic synthesis allows access complex materials in the context of fine chemicals, pharmaceuticals,...
A stereoselective two-carbon homologation protocol has been developed and applied to the asymmetric ...
Trimethyl (3R)-homocitrate 17, trimethyl (2S,3R)-[2-2H1]-homocitrate 17a and (2R,3R)-[2-2H1]-homocit...