Add to ORKGRationaleCocaine produces significant aversive/anxiogenic actions whose underlying neurobiology remains unclear. A possible substrate contributing to these actions is the serotonergic (5-HT) pathway projecting from the dorsal raphé (DRN) to regions of the extended amygdala, including the bed nucleus of the stria terminalis (BNST) which have been implicated in the production of anxiogenic states.ObjectivesThe present study examined the contribution of 5-HT signaling within the BNST to the anxiogenic effects of cocaine as measured in a runway model of drug self-administration.MethodsMale Sprague-Dawley rats were fitted with bilateral infusion cannula aimed at the BNST and then trained to traverse a straight alley once a day for a single 1&nbs...
RATIONALE: While individual differences in vulnerability to psychostimulants have been largely attri...
The hippocampus is an important mediator of learning and reinforcement, but its role in cocaine effe...
RATIONALE: While individual differences in vulnerability to psychostimulants have been largely attri...
Consistent with the Opponent Process Theory of motivated behavior, cocaine administration produces d...
Consistent with the Opponent Process Theory of motivated behavior, cocaine administration produces d...
Self-administration of cocaine produces an initially euphoric or “high” state, following shortly aft...
Cocaine addiction and depression are comorbid disorders. Although it is well recognized that 5-hydro...
In addition to its initial rewarding effects, cocaine has been shown to produce profound negative/an...
Cocaine has long been known to produce an initial "high" followed by an aversive/anxiogenic "crash"....
The serotonin 5-HT2A and 5-HT2C receptors regulate the capacity of acute cocaine to augment behavior...
Compulsive drug use despite adverse consequences defines addiction. While mesolimbic dopamine signal...
Numerous clinical studies have indicated that lifetime anxiety is highly prevalent in drug addicts. ...
abstract: Substance abuse disorders affect 15.3 million people worldwide. The field has primarily fo...
RATIONALE: While individual differences in vulnerability to psychostimulants have been largely attri...
RATIONALE: While individual differences in vulnerability to psychostimulants have been largely attri...
RATIONALE: While individual differences in vulnerability to psychostimulants have been largely attri...
The hippocampus is an important mediator of learning and reinforcement, but its role in cocaine effe...
RATIONALE: While individual differences in vulnerability to psychostimulants have been largely attri...
Consistent with the Opponent Process Theory of motivated behavior, cocaine administration produces d...
Consistent with the Opponent Process Theory of motivated behavior, cocaine administration produces d...
Self-administration of cocaine produces an initially euphoric or “high” state, following shortly aft...
Cocaine addiction and depression are comorbid disorders. Although it is well recognized that 5-hydro...
In addition to its initial rewarding effects, cocaine has been shown to produce profound negative/an...
Cocaine has long been known to produce an initial "high" followed by an aversive/anxiogenic "crash"....
The serotonin 5-HT2A and 5-HT2C receptors regulate the capacity of acute cocaine to augment behavior...
Compulsive drug use despite adverse consequences defines addiction. While mesolimbic dopamine signal...
Numerous clinical studies have indicated that lifetime anxiety is highly prevalent in drug addicts. ...
abstract: Substance abuse disorders affect 15.3 million people worldwide. The field has primarily fo...
RATIONALE: While individual differences in vulnerability to psychostimulants have been largely attri...
RATIONALE: While individual differences in vulnerability to psychostimulants have been largely attri...
RATIONALE: While individual differences in vulnerability to psychostimulants have been largely attri...
The hippocampus is an important mediator of learning and reinforcement, but its role in cocaine effe...
RATIONALE: While individual differences in vulnerability to psychostimulants have been largely attri...
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