Add to ORKGStatin responsiveness is an area of great research interest given the success of the drug class in the treatment of hypercholesterolemia and in primary and secondary prevention of cardiovascular disease. Interrogation of the patient's genome for gene variants will eventually guide anti-hyperlipidemic intervention. In this review, we discuss methodological approaches to discover genetic markers predictive of class-wide and drug-specific statin efficacy and safety. Notable pharmacogenetic findings are summarized from hypothesis-free genome wide and hypothesis-led candidate gene association studies. Physiogenomic models and clinical decision support systems will be required for DNA-guided statin therapy to reach practical use in medicine
THERAPY WITH 3-HYDROXY-3-methylglutaryl-coenzyme A(HMG-CoA) reductase inhibi-tors (statins) lowers t...
Cardiovascular diseases are the main cause of death worldwide. The ability to accurately define indi...
Statins are the most commonly prescribed drugs in the United States and are extremely effective in r...
The prevention of cardiovascular disease is critically dependent on lipid-lowering therapy, includin...
Statins have been used for decades as a successful cholesterol-lowering class of medicines. Statins ...
Indicated for treating hyperlipidemias and for the prevention of cardiovascular disease (CVD), stati...
Statins are the most commonly prescribed class of drug worldwide and therapy is highly effective in ...
Cardiovascular drugs are abundantly prescribed to reduce risk of cardiovascular disease. Treatment w...
It was investigated whether pharmacogenetic factors, both as single polymorphism and as gene-gene in...
Although statins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) have proven effective in redu...
Aim of this thesis was to investigate pharmacogenetic effects on response to statin treatment and th...
Statins are efficacious lipid-lowering drugs used for prevention of cardiovascular complications in ...
The exponential expansion of genomic data coupled with the lack of appropriate clinical categorizati...
Metabolic syndrome is one of the most prevalent conditions in our population. Among components of th...
A drug that is effective in one group of patients may have a reduced or no effect in other patients....
THERAPY WITH 3-HYDROXY-3-methylglutaryl-coenzyme A(HMG-CoA) reductase inhibi-tors (statins) lowers t...
Cardiovascular diseases are the main cause of death worldwide. The ability to accurately define indi...
Statins are the most commonly prescribed drugs in the United States and are extremely effective in r...
The prevention of cardiovascular disease is critically dependent on lipid-lowering therapy, includin...
Statins have been used for decades as a successful cholesterol-lowering class of medicines. Statins ...
Indicated for treating hyperlipidemias and for the prevention of cardiovascular disease (CVD), stati...
Statins are the most commonly prescribed class of drug worldwide and therapy is highly effective in ...
Cardiovascular drugs are abundantly prescribed to reduce risk of cardiovascular disease. Treatment w...
It was investigated whether pharmacogenetic factors, both as single polymorphism and as gene-gene in...
Although statins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) have proven effective in redu...
Aim of this thesis was to investigate pharmacogenetic effects on response to statin treatment and th...
Statins are efficacious lipid-lowering drugs used for prevention of cardiovascular complications in ...
The exponential expansion of genomic data coupled with the lack of appropriate clinical categorizati...
Metabolic syndrome is one of the most prevalent conditions in our population. Among components of th...
A drug that is effective in one group of patients may have a reduced or no effect in other patients....
THERAPY WITH 3-HYDROXY-3-methylglutaryl-coenzyme A(HMG-CoA) reductase inhibi-tors (statins) lowers t...
Cardiovascular diseases are the main cause of death worldwide. The ability to accurately define indi...
Statins are the most commonly prescribed drugs in the United States and are extremely effective in r...