Eicosanoids are biologically active lipid signaling molecules derived from polyunsaturated fatty acids. Many of the actions of eicosanoid metabolites formed by cyclooxygenase and lipoxygenase enzymes have been characterized, however, the epoxy-fatty acids (EpFAs) formed by cytochrome P450 enzymes are newly described by comparison. The EpFA metabolites modulate a diverse set of physiologic functions that include inflammation and nociception among others. Regulation of EpFAs occurs primarily via release, biosynthesis and enzymatic transformation by the soluble epoxide hydrolase (sEH). Targeting sEH with small molecule inhibitors has enabled observation of the biological activity of the EpFAs in vivo in animal models, greatly contributing to t...
Dr. Bernard Brodie's legacy is built on fundamental discoveries in pharmacology and drug metabolism ...
Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four differen...
Inflammation plays a crucial role in the initiation and development of a wide range of systemic illn...
The role of lipids in pain signaling is well established and built on decades of knowledge about the...
Chronic pain is a complicated condition which causes substantial physical, emotional, and financial ...
Polyunsaturated fatty acids (PUFAs) are essential FAs for human health. Cytochrome P450 oxygenates P...
There is currently an urgent need for safe and effective treatment options for chronic diseases, esp...
Epoxygenated fatty acids (EpFAs), which are lipid mediators produced by cytochrome P450 epoxygenases...
The soluble epoxide hydrolase (sEH) is a regulatory enzyme responsible for the metabolism of bioacti...
Neuroinflammation is a physiologic response aimed at protecting the central nervous system during in...
We need better medicines to control acute and chronic pain. Fatty acid amide hydrolase (FAAH) and so...
It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the metabolism ...
Epoxyeicosatrienoic acids (EETs) are derived from cytochrome P450 (CYP)-catalyzed epoxygenation of a...
The arachidonic acid cascade is arguably the most widely known biologic regulatory pathway. Decades ...
Cytochrome P450 (CYP) metabolism of arachidonic acid (ARA) produces epoxy fatty acids (EpFAs) such a...
Dr. Bernard Brodie's legacy is built on fundamental discoveries in pharmacology and drug metabolism ...
Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four differen...
Inflammation plays a crucial role in the initiation and development of a wide range of systemic illn...
The role of lipids in pain signaling is well established and built on decades of knowledge about the...
Chronic pain is a complicated condition which causes substantial physical, emotional, and financial ...
Polyunsaturated fatty acids (PUFAs) are essential FAs for human health. Cytochrome P450 oxygenates P...
There is currently an urgent need for safe and effective treatment options for chronic diseases, esp...
Epoxygenated fatty acids (EpFAs), which are lipid mediators produced by cytochrome P450 epoxygenases...
The soluble epoxide hydrolase (sEH) is a regulatory enzyme responsible for the metabolism of bioacti...
Neuroinflammation is a physiologic response aimed at protecting the central nervous system during in...
We need better medicines to control acute and chronic pain. Fatty acid amide hydrolase (FAAH) and so...
It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the metabolism ...
Epoxyeicosatrienoic acids (EETs) are derived from cytochrome P450 (CYP)-catalyzed epoxygenation of a...
The arachidonic acid cascade is arguably the most widely known biologic regulatory pathway. Decades ...
Cytochrome P450 (CYP) metabolism of arachidonic acid (ARA) produces epoxy fatty acids (EpFAs) such a...
Dr. Bernard Brodie's legacy is built on fundamental discoveries in pharmacology and drug metabolism ...
Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four differen...
Inflammation plays a crucial role in the initiation and development of a wide range of systemic illn...