Organophosphate (OP) nerve agents and pesticides trigger a common mechanism of neurotoxicity resulting from critical targeting and inhibition of acetylcholinesterases (AChE) in central and peripheral synapses in the cholinergic nervous system. Therapeutic countermeasures have thus focused on either administering an oxime post-exposure, that can rapidly reactivate OP-inhibited AChE, or by preventing OP poisoning through administering pre-exposure treatments that scavenge OPs before they inhibit their physiological AChE targets. While several pyridinium aldoxime antidotes are currently approved, their utility is impaired due to their inability to cross the blood-brain barrier (BBB) efficiently. The present study utilized a macaque (Ma) model ...
Realistic scenarios for low-level exposure to nerve agents will often involve exposures over several...
© 2017 International Society for Neurochemistry.Organophosphorus agents (OPs) irreversibly inhibit a...
Background: Oxime K033 was considered a promising drug candidate originally developed for the treatm...
Fatalities from organophosphate (OP) insecticide result from both occupational and deliberate exposu...
The ability of oximes to reactivate organophosphorus nerve agent-inhibited acetylcholinesterase (ACh...
Organophosphates (OPs) are used in agriculture via pesticides, and warfare and terrorism via nerve a...
Organophosphorus (OP) pesticides are a diverse class of acetylcholinesterase (AChE) inhibitors that ...
The toxic effects of nerve agents and organophosphorous pesticides are mainly due to inhibition of A...
International audienceNerve agents, the deadliest chemical warfare agents, are potent inhibitors of ...
International audienceNerve agents, the deadliest chemical warfare agents, are potent inhibitors of ...
Subchronic pretreatment with physostigmine (PHY) (0.0125 mg/kg/h) leading to a blood acetylcholinest...
Recent assassinations and terrorist attacks demonstrate the need for a more effective antidote again...
Recent assassinations and terrorist attacks demonstrate the need for a more effective antidote again...
Inhibition of acetylcholinesterase (AChE) is regarded as the primary toxic mechanism of organophosph...
International audienceBackground: Human exposure to organophosphorus compounds employed as pesticide...
Realistic scenarios for low-level exposure to nerve agents will often involve exposures over several...
© 2017 International Society for Neurochemistry.Organophosphorus agents (OPs) irreversibly inhibit a...
Background: Oxime K033 was considered a promising drug candidate originally developed for the treatm...
Fatalities from organophosphate (OP) insecticide result from both occupational and deliberate exposu...
The ability of oximes to reactivate organophosphorus nerve agent-inhibited acetylcholinesterase (ACh...
Organophosphates (OPs) are used in agriculture via pesticides, and warfare and terrorism via nerve a...
Organophosphorus (OP) pesticides are a diverse class of acetylcholinesterase (AChE) inhibitors that ...
The toxic effects of nerve agents and organophosphorous pesticides are mainly due to inhibition of A...
International audienceNerve agents, the deadliest chemical warfare agents, are potent inhibitors of ...
International audienceNerve agents, the deadliest chemical warfare agents, are potent inhibitors of ...
Subchronic pretreatment with physostigmine (PHY) (0.0125 mg/kg/h) leading to a blood acetylcholinest...
Recent assassinations and terrorist attacks demonstrate the need for a more effective antidote again...
Recent assassinations and terrorist attacks demonstrate the need for a more effective antidote again...
Inhibition of acetylcholinesterase (AChE) is regarded as the primary toxic mechanism of organophosph...
International audienceBackground: Human exposure to organophosphorus compounds employed as pesticide...
Realistic scenarios for low-level exposure to nerve agents will often involve exposures over several...
© 2017 International Society for Neurochemistry.Organophosphorus agents (OPs) irreversibly inhibit a...
Background: Oxime K033 was considered a promising drug candidate originally developed for the treatm...