Add to ORKGDeficient progranulin levels cause dose-dependent neurological syndromes: haploinsufficiency leads to frontotemporal lobar degeneration (FTLD) and nullizygosity produces adult-onset neuronal ceroid lipofuscinosis. Mechanisms controlling progranulin levels are largely unknown. To better understand progranulin regulation, we performed a genome-wide RNAi screen using an ELISA-based platform to discover genes that regulate progranulin levels in neurons. We identified 830 genes that raise or lower progranulin levels by at least 1.5-fold in Neuro2a cells. When inhibited by siRNA or some by submicromolar concentrations of small-molecule inhibitors, 33 genes of the druggable genome increased progranulin levels in mouse primary cortical neurons; sev...
Null mutations in the progranulin gene (PGRN) have been identified as a major cause of frontotempora...
Background: Heterozygous loss-of-function mutations in the progranulin gene (GRN) lead to frontotemp...
Frontotemporal degeneration (FTD) is a complex disease presenting as a spectrum of clinical disorder...
The discovery that heterozygous and homozygous mutations in the gene encoding progranulin are causal...
Frontotemporal lobar degeneration (FTLD) is a devastating, late-onset neurodegenerative disorder tha...
Progranulin (PGRN) is a widely expressed cysteine-rich, secreted glycoprotein with growth factor-lik...
Recent studies suggest progranulin (GRN) is a neurotrophic factor. Loss-of-function mutations in the...
The reduced production or activity of the cysteine-rich glycoprotein progranulin is responsible for ...
Background: Progranulin deficiency due to heterozygous null mutations in the GRN ge...
Frontotemporal lobar degeneration (FTLD) is a devastating, clinically heterogeneous neurodegenerativ...
Abstract Background Loss of function mutations in progranulin (GRN) are a major cause of frontotempo...
Loss-of-function mutations in progranulin (GRN) that result in haploinsufficiency of the progranulin...
Background and Objective: Reduced progranulin levels are a hallmark of frontotemporal dementia (FTD)...
Loss-of-function mutations in the gene encoding the growth factor progranulin cause degeneration of ...
Progranulin (GRN) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficienc...
Null mutations in the progranulin gene (PGRN) have been identified as a major cause of frontotempora...
Background: Heterozygous loss-of-function mutations in the progranulin gene (GRN) lead to frontotemp...
Frontotemporal degeneration (FTD) is a complex disease presenting as a spectrum of clinical disorder...
The discovery that heterozygous and homozygous mutations in the gene encoding progranulin are causal...
Frontotemporal lobar degeneration (FTLD) is a devastating, late-onset neurodegenerative disorder tha...
Progranulin (PGRN) is a widely expressed cysteine-rich, secreted glycoprotein with growth factor-lik...
Recent studies suggest progranulin (GRN) is a neurotrophic factor. Loss-of-function mutations in the...
The reduced production or activity of the cysteine-rich glycoprotein progranulin is responsible for ...
Background: Progranulin deficiency due to heterozygous null mutations in the GRN ge...
Frontotemporal lobar degeneration (FTLD) is a devastating, clinically heterogeneous neurodegenerativ...
Abstract Background Loss of function mutations in progranulin (GRN) are a major cause of frontotempo...
Loss-of-function mutations in progranulin (GRN) that result in haploinsufficiency of the progranulin...
Background and Objective: Reduced progranulin levels are a hallmark of frontotemporal dementia (FTD)...
Loss-of-function mutations in the gene encoding the growth factor progranulin cause degeneration of ...
Progranulin (GRN) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficienc...
Null mutations in the progranulin gene (PGRN) have been identified as a major cause of frontotempora...
Background: Heterozygous loss-of-function mutations in the progranulin gene (GRN) lead to frontotemp...
Frontotemporal degeneration (FTD) is a complex disease presenting as a spectrum of clinical disorder...