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Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates

  • Maza, Johnathan C
  • Ramsey, Alexandra V
  • Mehare, Meire
  • Krska, Shane W
  • Parish, Craig A
  • Francis, Matthew B
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Publication date
March 2020
Publisher
eScholarship, University of California

Abstract

A convenient two-step method is reported for the ligation of alkoxyamine- or hydrazine-bearing cargo to proline N-termini. Using this approach, bifunctional proline N-terminal bioconjugates are constructed and proline N-terminal proteins are immobilized

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