BackgroundVariants in multiple genetic loci modify the risk of non-alcoholic fatty liver disease (NAFLD) and cirrhosis but there are limited data on the quantitative impact of variant copies on liver fibrosis.AimTo investigate the effect of PNPLA3, TM6SF2, MBOAT7, GCKR and HSD17B13 genotype on liver fibrosis assessed by magnetic resonance elastography (MRE), a reproducible, accurate, continuous biomarker of liver fibrosis.MethodsThis is a cross-sectional analysis derived from a well-characterised cohort at risk for NAFLD who underwent genotyping and MRE assessment. Liver stiffness (LS) was estimated using MRE and advanced fibrosis was defined as liver stiffness ≥3.63 kilopascals (kPa). Univariable and multivariable linear and logistic ...
Background and Aims: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver dise...
Background & Aims: Genetic factors associated with nonalcoholic fatty liver disease (NAFLD) rema...
Tissue fibrosis is a highly heritable complex phenotype that has both core and disease-specific path...
Background and Aims Several genotypes associate with a worse histopathological profile in patients w...
Liver fibrosis is the main predictor of events in patients with nonalcoholic fatty liver disease (NA...
Non-alcoholic fatty liver disease (NAFLD) includes liver diseases ranging from simple steatosis to p...
N-terminal propeptide of type 3 procollagen (PRO-C3) is a biomarker of liver fibrosis in nonalcoholi...
The PNPLA3 p.I148M, TM6SF2 p.E167K, and MBOAT7 rs641738 variants represent genetic risk factors for ...
N-terminal propeptide of type 3 procollagen (PRO-C3) is a biomarker of liver fibrosis in nonalcoholi...
BACKGROUND AND AIMS: Variant in glucokinase regulatory protein (GCKR), associated with lipid and glu...
Nonalcoholic fatty liver disease (NAFLD), now the leading cause of liver damage worldwide, is epide-...
Non-alcoholic fatty liver disease (NAFLD) is frequent among obese individuals with metabolic syndrom...
BACKGROUND & AIMS: A common genetic variant near MBOAT7 (rs641738C>T) has been previously associated...
Background & Aims: A common genetic variant near MBOAT7 (rs641738C>T) has been previously associated...
Background and Aims: Intra-abdominal visceral fat accumulation and patatin-like phospholipase domain...
Background and Aims: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver dise...
Background & Aims: Genetic factors associated with nonalcoholic fatty liver disease (NAFLD) rema...
Tissue fibrosis is a highly heritable complex phenotype that has both core and disease-specific path...
Background and Aims Several genotypes associate with a worse histopathological profile in patients w...
Liver fibrosis is the main predictor of events in patients with nonalcoholic fatty liver disease (NA...
Non-alcoholic fatty liver disease (NAFLD) includes liver diseases ranging from simple steatosis to p...
N-terminal propeptide of type 3 procollagen (PRO-C3) is a biomarker of liver fibrosis in nonalcoholi...
The PNPLA3 p.I148M, TM6SF2 p.E167K, and MBOAT7 rs641738 variants represent genetic risk factors for ...
N-terminal propeptide of type 3 procollagen (PRO-C3) is a biomarker of liver fibrosis in nonalcoholi...
BACKGROUND AND AIMS: Variant in glucokinase regulatory protein (GCKR), associated with lipid and glu...
Nonalcoholic fatty liver disease (NAFLD), now the leading cause of liver damage worldwide, is epide-...
Non-alcoholic fatty liver disease (NAFLD) is frequent among obese individuals with metabolic syndrom...
BACKGROUND & AIMS: A common genetic variant near MBOAT7 (rs641738C>T) has been previously associated...
Background & Aims: A common genetic variant near MBOAT7 (rs641738C>T) has been previously associated...
Background and Aims: Intra-abdominal visceral fat accumulation and patatin-like phospholipase domain...
Background and Aims: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver dise...
Background & Aims: Genetic factors associated with nonalcoholic fatty liver disease (NAFLD) rema...
Tissue fibrosis is a highly heritable complex phenotype that has both core and disease-specific path...