A woman, age 44, with a positive anti-YO paraneoplastic cerebellar syndrome and normal imaging developed an ocular motor disorder including periodic alternating nystagmus (PAN), gaze-evoked nystagmus (GEN) and rebound nystagmus (RN). During fixation there was typical PAN but changes in gaze position evoked complex, time-varying oscillations of GEN and RN. To unravel the pathophysiology of this unusual pattern of nystagmus, we developed a mathematical model of normal function of the circuits mediating the vestibular-ocular reflex and gaze-holding including their adaptive mechanisms. Simulations showed that all the findings of our patient could be explained by two, small, isolated changes in cerebellar circuits: reducing the time constant of ...
<p>Acquired periodic alternating nystagmus (PAN) describes a horizontal jerk nystagmus that reverses...
Example of a patient with rebound nystagmus, where the oscillations alternate direction as the patie...
International audienceBACKGROUND: When patients with ocular motor deficits come to the clinic, in nu...
A woman, age 44, with a positive anti-YO paraneoplastic cerebellar syndrome and normal imaging devel...
: This is a 60-yo-woman with several years of worsening imbalance, diplopia (hers was actually unrel...
: 30-yo-man with the subacute onset of a cerebellar syndrome. After extensive evaluation and progres...
: This 50-yo-man complained of imbalance for several years and more recently oscillopsia. On examina...
Periodic alternating nystagmus (PAN) is a rare oscillatory ocular motor disorder. The effects of gra...
: This is a 30-year-old woman with a several year long history of imbalance due to cerebellar ataxia...
A brain stem/cerebellar neural integrator enables stable eccentric gaze. Cerebellar loss-of-function...
A 68-year-old female reported a 2-year history of progressive gait imbalance, falls, dizziness and v...
<p>Acquired periodic alternating nystagmus (PAN) describes a horizontal jerk nystagmus that reverses...
Periodic alternating nystagmus is a spontaneous horizontal nystagmus, present in central gaze, that ...
<p>Acquired periodic alternating nystagmus (PAN) describes a horizontal jerk nystagmus that reverses...
<p>Acquired periodic alternating nystagmus (PAN) describes a horizontal jerk nystagmus that reverses...
<p>Acquired periodic alternating nystagmus (PAN) describes a horizontal jerk nystagmus that reverses...
Example of a patient with rebound nystagmus, where the oscillations alternate direction as the patie...
International audienceBACKGROUND: When patients with ocular motor deficits come to the clinic, in nu...
A woman, age 44, with a positive anti-YO paraneoplastic cerebellar syndrome and normal imaging devel...
: This is a 60-yo-woman with several years of worsening imbalance, diplopia (hers was actually unrel...
: 30-yo-man with the subacute onset of a cerebellar syndrome. After extensive evaluation and progres...
: This 50-yo-man complained of imbalance for several years and more recently oscillopsia. On examina...
Periodic alternating nystagmus (PAN) is a rare oscillatory ocular motor disorder. The effects of gra...
: This is a 30-year-old woman with a several year long history of imbalance due to cerebellar ataxia...
A brain stem/cerebellar neural integrator enables stable eccentric gaze. Cerebellar loss-of-function...
A 68-year-old female reported a 2-year history of progressive gait imbalance, falls, dizziness and v...
<p>Acquired periodic alternating nystagmus (PAN) describes a horizontal jerk nystagmus that reverses...
Periodic alternating nystagmus is a spontaneous horizontal nystagmus, present in central gaze, that ...
<p>Acquired periodic alternating nystagmus (PAN) describes a horizontal jerk nystagmus that reverses...
<p>Acquired periodic alternating nystagmus (PAN) describes a horizontal jerk nystagmus that reverses...
<p>Acquired periodic alternating nystagmus (PAN) describes a horizontal jerk nystagmus that reverses...
Example of a patient with rebound nystagmus, where the oscillations alternate direction as the patie...
International audienceBACKGROUND: When patients with ocular motor deficits come to the clinic, in nu...