Add to ORKGSelective catalytic functionalization of C(sp 3)-H bonds represents a powerful means to access valuable products from ubiquitous starting materials. In a recent JACS paper, Arnold and co-workers engineered P450 nitrene transferases to aminate unactivated C(sp 3)-H bonds with excellent site- and stereoselectivities
One of the most important challenges in chemistry is the creation of new catalysts. Nature excels at...
SummaryModern tools for enzyme discovery combined with the development of increasingly reliable stra...
The selective functionalization of ubiquitous C-H bonds can greatly streamline the construction of c...
Primary amine is one of the most prevalent moieties in synthetic intermediates and pharmaceutical co...
International audienceA catalytic intermolecular amination of non-activated tertiary C(sp 3)−H bonds...
Engineered heme protein biocatalysts provide an efficient and sustainable approach to develop amine-...
We recently demonstrated that variants of cytochrome P450<sub>BM3</sub> (CYP102A1) catalyze the inse...
Enantioselective C–H amidation offers attractive means to assemble C–N bonds to synthesize high-adde...
Synthetic methods to selectively convert C–H bonds, a prevalent motif in organic molecules, into fun...
Cytochrome P450 enzymes were recently engineered to catalyze the C–H amination reaction of aryl sulf...
Nitrogen activation: Though P450 enzymes are masters of oxygen activation and insertion into C-H bon...
A major challenge in carbon‒hydrogen (C‒H) bond functionalization is to have the catalyst control pr...
Carbon-nitrogen bond formation from inert C-H bonds is an ideal organic transformation and a highly ...
C–H bonds are ubiquitous structural units of organic molecules. Although these bonds are generally c...
Modern tools for enzyme discovery combined with the development of increasingly reliable strategies ...
One of the most important challenges in chemistry is the creation of new catalysts. Nature excels at...
SummaryModern tools for enzyme discovery combined with the development of increasingly reliable stra...
The selective functionalization of ubiquitous C-H bonds can greatly streamline the construction of c...
Primary amine is one of the most prevalent moieties in synthetic intermediates and pharmaceutical co...
International audienceA catalytic intermolecular amination of non-activated tertiary C(sp 3)−H bonds...
Engineered heme protein biocatalysts provide an efficient and sustainable approach to develop amine-...
We recently demonstrated that variants of cytochrome P450<sub>BM3</sub> (CYP102A1) catalyze the inse...
Enantioselective C–H amidation offers attractive means to assemble C–N bonds to synthesize high-adde...
Synthetic methods to selectively convert C–H bonds, a prevalent motif in organic molecules, into fun...
Cytochrome P450 enzymes were recently engineered to catalyze the C–H amination reaction of aryl sulf...
Nitrogen activation: Though P450 enzymes are masters of oxygen activation and insertion into C-H bon...
A major challenge in carbon‒hydrogen (C‒H) bond functionalization is to have the catalyst control pr...
Carbon-nitrogen bond formation from inert C-H bonds is an ideal organic transformation and a highly ...
C–H bonds are ubiquitous structural units of organic molecules. Although these bonds are generally c...
Modern tools for enzyme discovery combined with the development of increasingly reliable strategies ...
One of the most important challenges in chemistry is the creation of new catalysts. Nature excels at...
SummaryModern tools for enzyme discovery combined with the development of increasingly reliable stra...
The selective functionalization of ubiquitous C-H bonds can greatly streamline the construction of c...