BackgroundMucin disulfide cross-links mediate pathologic mucus formation in muco-obstructive lung diseases. MUC-031, a novel thiol-modified carbohydrate compound, cleaves disulfides to cause mucolysis. The aim of this study was to determine the mucolytic and therapeutic effects of MUC-031 in sputum from patients with cystic fibrosis (CF) and mice with muco-obstructive lung disease (βENaC-Tg mice).MethodsWe compared the mucolytic efficacy of MUC-031 and existing mucolytics (N-acetylcysteine (NAC) and recombinant human deoxyribonuclease I (rhDNase)) using rheology to measure the elastic modulus (G') of CF sputum, and we tested effects of MUC-031 on airway mucus plugging, inflammation and survival in βENaC-Tg mice to determine its mucolytic ef...
AbstractBackgroundThere is conflicting evidence about the importance of airway mucins (MUC5AC and MU...
The host- and bacteria-derived extracellular polysaccharide coating of the lung is a considerable ch...
Dehydration of the mucus in the lung airway is a hallmark of cystic fibrosis (CF) airway disease. In...
Rationale: Airways obstruction with thick, adherent mucus is a pathophysiologic and clinical feature...
Airway mucus in cystic fibrosis (CF) is highly elastic, but themechanism behind this pathology is un...
Thiol-based drugs are considered as mucolytics because they decrease the viscosity and mostly decrea...
Recent evidence suggests that inadequate hydration of airway surfaces is a common mechanism in the p...
MUC5AC, a major gel-forming mucin expressed in the lungs, is secreted at increased rates in response...
International audienceMucin hypersecretion and mucus plugging in the airways are characteristic feat...
Airway mucus is essential for lung defense, but excessive mucus in asthma obstructs airflow, leading...
The host- and bacteria-derived extracellular polysaccharide coating of the lung is a considerable ch...
Background. Elevated levels of the cysteine protease cathepsin S (CatS) are associated with chronic ...
Background Therapeutic intervention in the pathophysiology of airway mucus hypersecretion is clinica...
Introduction: Genome-Wide Association Studies suggest glutathione S transferase C terminal domain (G...
Airway mucociliary clearance depends on the properties and volume of secreted mucus, ciliary functio...
AbstractBackgroundThere is conflicting evidence about the importance of airway mucins (MUC5AC and MU...
The host- and bacteria-derived extracellular polysaccharide coating of the lung is a considerable ch...
Dehydration of the mucus in the lung airway is a hallmark of cystic fibrosis (CF) airway disease. In...
Rationale: Airways obstruction with thick, adherent mucus is a pathophysiologic and clinical feature...
Airway mucus in cystic fibrosis (CF) is highly elastic, but themechanism behind this pathology is un...
Thiol-based drugs are considered as mucolytics because they decrease the viscosity and mostly decrea...
Recent evidence suggests that inadequate hydration of airway surfaces is a common mechanism in the p...
MUC5AC, a major gel-forming mucin expressed in the lungs, is secreted at increased rates in response...
International audienceMucin hypersecretion and mucus plugging in the airways are characteristic feat...
Airway mucus is essential for lung defense, but excessive mucus in asthma obstructs airflow, leading...
The host- and bacteria-derived extracellular polysaccharide coating of the lung is a considerable ch...
Background. Elevated levels of the cysteine protease cathepsin S (CatS) are associated with chronic ...
Background Therapeutic intervention in the pathophysiology of airway mucus hypersecretion is clinica...
Introduction: Genome-Wide Association Studies suggest glutathione S transferase C terminal domain (G...
Airway mucociliary clearance depends on the properties and volume of secreted mucus, ciliary functio...
AbstractBackgroundThere is conflicting evidence about the importance of airway mucins (MUC5AC and MU...
The host- and bacteria-derived extracellular polysaccharide coating of the lung is a considerable ch...
Dehydration of the mucus in the lung airway is a hallmark of cystic fibrosis (CF) airway disease. In...