Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with priori...
BACKGROUND: Various genome-wide association studies (GWAS) have been done in ischaemic stroke, ident...
Background: Various genome-wide association studies (GWAS) have been done in ischaemic stroke, ident...
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death world...
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conduc...
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conduc...
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conduc...
Background Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identi...
BACKGROUND AND PURPOSE: The contribution of genetics to stroke risk, and whether this differs for di...
SummaryBackgroundVarious genome-wide association studies (GWAS) have been done in ischaemic stroke, ...
BACKGROUND: Various genome-wide association studies (GWAS) have been done in ischaemic stroke, ident...
Background: Various genome-wide association studies (GWAS) have been done in ischaemic stroke, ident...
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death world...
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conduc...
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conduc...
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conduc...
Background Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identi...
BACKGROUND AND PURPOSE: The contribution of genetics to stroke risk, and whether this differs for di...
SummaryBackgroundVarious genome-wide association studies (GWAS) have been done in ischaemic stroke, ...
BACKGROUND: Various genome-wide association studies (GWAS) have been done in ischaemic stroke, ident...
Background: Various genome-wide association studies (GWAS) have been done in ischaemic stroke, ident...
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death world...