Precision oncology research is challenging outside the contexts of oncogenic addiction and/or targeted therapies. We previously showed that phosphoproteomics is a powerful approach to reveal patient subsets of interest characterized by the activity of a few kinases where the underlying genomics is complex. Here, we conduct a phosphoproteomic screening of samples from HER2-negative female breast cancer receiving neoadjuvant paclitaxel (N = 130), aiming to find candidate biomarkers of paclitaxel sensitivity. Filtering 11 candidate biomarkers through 2 independent patient sets (N = 218) allowed the identification of a subgroup of patients characterized by high levels of CDK4 and filamin-A who had a 90% chance of achieving a pCR in response to ...
The current therapy for ovarian cancer has advanced from alkylating agents, to a combination of carb...
Patient stratification has been instrumental for the success of targeted therapies in breast cancer....
Identifying single nucleotide polymorphisms (SNPs) that influence chemotherapy disposition may help ...
Breast cancer; Predictive markers; Proteomic analysisCáncer de mama; Marcadores predictivos; Análisi...
Triple-negative breast cancer (TNBC) lacks prognostic and predictive markers. Here, we use high-thro...
Increasingly, the effectiveness of adjuvant chemotherapy agents for breast cancer has been related t...
- Introduction:The cyclin-dependent kinases CDK4/6 are key regulators of the cell cycle entry, by ph...
Purpose: More than a third of primary breast cancer patients are treated with cytotoxic chemotherapy...
The landscape of genetic alterations that can lead to cancer is vast and complex. Precancerous cells...
Purpose: Most patients with ovarian cancer receive paclitaxel chemotherapy, but less than half respo...
Multiple Phos-tag-based screens were conducted in anti-tubulin drug (paclitaxel and nocodazole)-trea...
SummaryBackgroundAddition of taxanes to preoperative chemotherapy in breast cancer increases the pro...
BACKGROUND: Addition of taxanes to preoperative chemotherapy in breast cancer increases the proporti...
Breast cancer is considered the most frequently diagnosed cancer in women and the second most common...
Background: Paclitaxel is widely used as an adjuvant therapy in the treatment of breast cancer, yet ...
The current therapy for ovarian cancer has advanced from alkylating agents, to a combination of carb...
Patient stratification has been instrumental for the success of targeted therapies in breast cancer....
Identifying single nucleotide polymorphisms (SNPs) that influence chemotherapy disposition may help ...
Breast cancer; Predictive markers; Proteomic analysisCáncer de mama; Marcadores predictivos; Análisi...
Triple-negative breast cancer (TNBC) lacks prognostic and predictive markers. Here, we use high-thro...
Increasingly, the effectiveness of adjuvant chemotherapy agents for breast cancer has been related t...
- Introduction:The cyclin-dependent kinases CDK4/6 are key regulators of the cell cycle entry, by ph...
Purpose: More than a third of primary breast cancer patients are treated with cytotoxic chemotherapy...
The landscape of genetic alterations that can lead to cancer is vast and complex. Precancerous cells...
Purpose: Most patients with ovarian cancer receive paclitaxel chemotherapy, but less than half respo...
Multiple Phos-tag-based screens were conducted in anti-tubulin drug (paclitaxel and nocodazole)-trea...
SummaryBackgroundAddition of taxanes to preoperative chemotherapy in breast cancer increases the pro...
BACKGROUND: Addition of taxanes to preoperative chemotherapy in breast cancer increases the proporti...
Breast cancer is considered the most frequently diagnosed cancer in women and the second most common...
Background: Paclitaxel is widely used as an adjuvant therapy in the treatment of breast cancer, yet ...
The current therapy for ovarian cancer has advanced from alkylating agents, to a combination of carb...
Patient stratification has been instrumental for the success of targeted therapies in breast cancer....
Identifying single nucleotide polymorphisms (SNPs) that influence chemotherapy disposition may help ...