Hyponatraemia and changes in natraemia during hospitalization for acute heart failure and associations with in-hospital and long-term outcomes - from the ESC-HFA EORP Heart Failure Long-Term Registry.
- Kapłon-Cieślicka, A
- Benson, L
- Chioncel, O
- Crespo-Leiro, MG
- Coats, AJS
- Anker, SD
- Ruschitzka, F
- Hage, C
- Drożdż, J
- Seferovic, P
- Rosano, GMC
- Piepoli, M
- Mebazaa, A
- McDonagh, T
- Lainscak, M
- Savarese, G
- Ferrari, R
- Mullens, W
- Bayes-Genis, A
- Maggioni, AP
- Lund, LH
- on behalf of the Heart Failure Association (HFA) of the European
DOIAbstract
AIMS: To comprehensively assess hyponatraemia in acute heart failure (AHF) regarding prevalence, associations, hospital course, and post-discharge outcomes. METHODS AND RESULTS: Of 8298 patients in the European Society of Cardiology Heart Failure Long-Term Registry hospitalized for AHF with any ejection fraction, 20% presented with hyponatraemia (serum sodium <135 mmol/L). Independent predictors included lower systolic blood pressure, estimated glomerular filtration rate (eGFR) and haemoglobin, along with diabetes, hepatic disease, use of thiazide diuretics, mineralocorticoid receptor antagonists, digoxin, higher doses of loop diuretics, and non-use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers and beta-blockers....
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